益智仁化学成分的分离与鉴定  

Isolation and Identification of Chemical Constituents from Alpinia oxyphylla

作　　者：石绍淮[1] 张晨宁[1] 刘爱敬[1] 李欢[1] 毕开顺[2] 贾英[1] 

机构地区：[1]沈阳药科大学中药学院,沈阳110016 [2]沈阳药科大学药学院,沈阳110016

出　　处：《中国实验方剂学杂志》2013年第17期97-100,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：辽宁省科学技术计划项目(2011412004-1);辽宁省教育厅创新团队项目(2009T097)

摘　　要：目的:对益智仁的化学成分进行研究。方法:采用硅胶、凝胶柱色谱和制备高效液相色谱等分离方法对益智仁95%乙醇溶液提取物进行成分分离,通过谱学分析方法结合理化性质进行结构鉴定。结果:共分离得到9个化合物,分别鉴定为teuhetenone A(1)、α-羟甲基糠醛(α-hydroxymethyl furfural,2)、原儿茶酸(protocatechuic acid,3)、邻苯二甲酸二丁酯(dibutylphthalate,4)、丁二酸-1-(5-甲酰基-2-呋喃)甲酯-4-正丁酯[1-n-butyl-4-(5'-formyl-2'-furanyl)methyl succinate,5]、杨芽黄素(tectochrysin,6)、β-谷甾醇(β-sitosterolum,7)、胡萝卜苷(daucosterol,8)、正壬烷基木糖醇(1-O-nonyl-xylitol,9)。结论:化合物2,4,5,9为首次从益智仁中分离得到,化合物9是新的天然产物。Objective：To study the chemical constituents of Alpinia oxyphylla.Method：The chemical constituents of 95% ethanol extract of A.oxyphylla were isolated by silica gel column chromatography,sephadex LH-20 column chromatography,together with preparative liquid chromatography method,and the structures were identified by means of NMR spectral analysis and physico-chemical properties.Result：Nine compounds were obtained and elucidated as teuhetenone A（1）,α-hydroxymethyl furfural（2）,protocatechuic acid（3）,dibutyl phthalate（4）,1-n-butyl-4-（5’-formyl-2’-furanyl） methyl succinate（5）,tectochrysin（6）,β-sitosterolum（7）,daucosterol（8）,1-O-nonyl-xylitol（9）.Conclusion：Compounds 2,4,5 and 9 were isolated from this plant for the first time,and compound 9 was a new natural product.

关 键 词：益智仁 化学成分 结构鉴定 

分 类 号：R284.1[医药卫生—中药学]