9种蓼科植物抗菌活性  

Antibacterial Activities of Nine Polygonaceae Plants

作　　者：王培卿[1] 张橡楠 刘瑜新[1,3] 李昌勤[1] 康文艺[1] 

机构地区：[1]河南大学中药研究所,河南开封475004 [2]河南医药技师学院,河南开封475008 [3]河南大学淮河医院,河南开封475001

出　　处：《中国实验方剂学杂志》2013年第17期109-112,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：河南省教育厅自然科学基金(2009B360001);河南大学校内基金(2011YBZR015)

摘　　要：目的:研究9种蓼科植物的体外抗菌活性。方法:采用纸片扩散法和多孔板法研究9种蓼科植物的不同提取物对金黄色葡萄球菌(SA)、耐甲氧西林的金黄色葡萄球菌(MRSA)和β-内酰胺酶阳性的金黄色葡萄球菌(ESBLs-SA)的抑制活性。结果:四季红甲醇提取物和四季红乙酸乙酯提取物质量浓度在50 g·L-1对SA,MRSA和ESBLs-SA的抑菌圈直径较大,其中四季红乙酸乙酯提取物对3种菌均有抑制作用,MIC全部为0.062 5 g·L-1;多孔板法中,辣蓼乙酸乙酯提取物(IC500.45 g·L-1)活性最好。结论:实验证明蓼科植物提取物对SA,MRSA,ESBLs-SA有较好的抑制作用,尤其是四季红和辣蓼的抗菌活性较显著。Objective：To evaluate the antimicrobial activity of nine plants of Polygonaceae in vitro.Method：Disc diffusion methods and porous plate methods were used to evaluate the inhibitory activity of different extracts of nine Polygonaceae plants against Staphylococcus aureus（SA）,Methicillin-resistant Staphylococcus aureus（MRSA） and ESBLs-SA.Result：The results indicated that methanol extract of Polygonum capitatum D.Don and ethyl acetate extract of P.capitatum at the concentration of 50 g·L-1 had a larger inhibiting diameter than that of other extracts of plants,among them MIC in the ethyl acetate extract of P.capitatum against SA,MRSA and ESBLs-SA was 0.062 5 g·L-1.The ethyl acetate extract of P.hydropiper L.var hispidum（Jook.F.） Steward.showed the highest inhibitory effect（IC50 0.45 g·L-1） in porous plate methods.Conclusion：Results showed that nine plants extracts of Polygonaceae have better inhibitory activity against the tested bacteria,especially P.capitatum and P.hydropiper L.var hispidum（Jook.F.） Steward.showed more significant antimicrobial activity.

关 键 词：蓼科 抗菌活性 金黄色葡萄球菌 耐甲氧西林的金黄色葡萄球菌 β-内酰胺酶阳性的金黄色葡萄球菌 

分 类 号：R285.5[医药卫生—中药学]