动态血糖监测评价地特胰岛素与甘精胰岛素的降糖疗效  

Dynamic Glucose Monitoring for the Evaluation of Clinical Efficacy of Insulin Detemir vs Insulin Glargine

作　　者：吴广飞[1] 张运捷[1] 铉绪敏[1] 刘博伟[1] 尹福在[1] 

机构地区：[1]河北医科大学附属秦皇岛市第一医院内分泌科,河北秦皇岛066000

出　　处：《医学临床研究》2013年第8期1487-1489,共3页Journal of Clinical Research

摘　　要：【目的】探讨动态血糖监测系统（DGMS）比较地特胰岛素（诺和平）与甘精胰岛素（来得时）的有效性和安全性。【方法】将2012年6月至2012年12月秦皇岛市第一医院的20例2型糖尿病患者随机分为A、B两组各10例，在应用二甲双胍基础上，分别加用来得时和诺和平控制血糖，同时应用DGMS监测血糖。【结果】两组患者24小时平均血糖（24hMBG）、24小时曲线下面积（24hAUC）、早餐后5小时曲线下面积（BP5hAUC）、午餐后5小时曲线下面积（LP5hAUC）、晚餐后5小时曲线下面积（SP5hAUC）、夜间0点到晨7点曲线下面积（7hAUC）、日内平均血糖波动幅度（MAGE）、胰岛素日用量（Dose）均无显著性差异（P〉0．05），两组患者均无低血糖发生。【结论】诺和平与来得时疗效相当，均能有效、安全的控制24h血糖。[Objective] To compare the effectiveness and safety of insulin detemir vs insulin glargine by u- sing dynamic glucose monitoring system（DGMS）. [Methods] Twenty patients with type 2 diabetes mellitus in First Hospital of Qinhuangdao city from June 2012 to Dec. 2012 were randomly divided into group A and group B with 10 cases in each. All patients were given metformin. Group A and group A were additionally giv- en insulin glargine or insulin detemir, respectively. At the same time, DGMS was used to monitor blood glu- cose. [Results] There was no significant differences in 24h mean blood glucose（MBG）, 24h area below the curve（24hAUC）, the area below the curve 5h after breakfast（BP5hAUC）, the area below the curve 5h after lunch（LP5hAUC）, the area below the curve 5h after dinner（SP5hAUC）, the area below the curve from 0：00 to 7：00am, mean amplitude of blood glucose fluctuation one day and daily dose of insulin between two groups （ P 〉0.05）. No hypoglycemia occurred in two groups. [Conclusion] Clinical efficacy of insulin detemir is the same as insulin glargine. Both insulin detemir and insulin glargine can effectively and safely control 24h-blood glucose.

关 键 词：胰岛素 药理学 血糖自我监测 

分 类 号：R977.15[医药卫生—药品]