小剂量氨氯地平联合替米沙坦治疗高血压的临床疗效观察  

Observation on Clinical Efficacy of Small Dose of Amlodipine Combined with Telmisartan for the Treat- ment of Hypertension

作　　者：曹桂秋[1] 窦媛媛[1] 

机构地区：[1]新疆医科大学第五附属医院,新疆乌鲁木齐830011

出　　处：《医学临床研究》2013年第8期1558-1559,共2页Journal of Clinical Research

摘　　要：【目的】探讨运用小剂量氨氯地平联合替米沙坦治疗高血压患者的临床疗效。【方法】选择本院2010年8月至2012年8月间进行诊治的172例高血压患者，将其随机分为对照组和观察组。对照组患者口服替米沙坦进行治疗，观察组患者在口服替米沙坦的基础上加用小剂量氨氯地平，比较两组患者的临床疗效。【结果】治疗后，两组患者的血压水平与治疗前相比均有所下降，观察组患者的降压迭标率在1个月末、3个月末、6个月末均比对照组高，且两组相比较差异有显著性（P〈0．05），两组患者不良反应发生率未见明显差异（P〉0．05）。【结论】在治疗高血压时应用小剂量氨氯地平联合替米沙坦进行治疗的临床效果显著，血压达标速度快，同时不增加患者出现不良反应的几率，值得在临床上推广使用。[Objective]To explore the clinical efficacy of small dose of amlodipine combined with telmisartan for the treatment of hypertensive patients. [Methods]Totally 172 patients with hypertension diagnosed and treated in our hospital form Aug. 2010 to Aug. 2012 were chosen and randomly divided into control group and treatment group. Patients in con- trol group were treated with oral telmisartan, while the patients in treatment group were treated with small dose of amlo- dipine based on oral telmisartan. Clinical efficacy was compared between two groups. [Results]Compared with before treatment, blood pressure levels in two groups after treatment were decreased. After treatment, the control rate of blood pressure in treatment group at the end of 1, 3 and 6 months was higher than that in control group, and there was signifi- cant difference（ P 〈0.05）. There was no significant difference in the incidence of adverse effect between two groups（ P 〉0.05）. [Conclusion]Small dose of amlodipine combined with telmisartan for the treatment of hypertension has more significant clinical efficacy and rapid blood pressure control, and can not increase the incidence of adverse effect. There- fore, it is worthy of clinical promotion.

关 键 词：高血压 药物疗法 氨氯地平 投药和剂量 

分 类 号：R544.1[医药卫生—心血管疾病]