雾化吸入长托宁对单肺通气期间肺内分流和氧合的影响  

Impact of Aerosolized Penehyclidine Hydrochloride Inhalation on Intrapulmonary Shunt and Oxygenation During One-lung Ventilation

作　　者：郑贤军[1] 姜金玉[1] 孔高茵[1] 张宇[1] 

机构地区：[1]湖南省人民医院,湖南长沙410005

出　　处：《医学临床研究》2013年第8期1593-1595,共3页Journal of Clinical Research

摘　　要：【目的】观察单肺通气（on．1ungventilation，OLV）期间雾化吸入长托宁对肺内分流率（Qs／Qt）、氧合指数（oxygenationindex，0I）和血乳酸（bloodlactieacid，BLA）水平的影响。【方法】选择28例0LV行开胸手术的患者，随机分长托宁组（P组，于0LV期间雾化吸入长托宁）和对照组（C组）。分别于OLV前15min（T0）、OLV15rain（T1）、OLV45min（T2）抽动脉血与混合静脉血行血气分析及BLA测定，计算Qs／Qt与0I。【结果】0LV后两组0I均下降，但P组较c组下降缓慢，且P组Tz较T。有所回升；OLV后两组Qs／Qt和BLA均增加，但P组比C组增加较慢，且P组T2较T1有所下降。【结论】0LV期间雾化吸入长托宁能改善氧舍，降低肺内分流。[Objective]To observe the impact of aerosolized penehyclidine hydrochloride inhalation on in- trapulmonary shunt fraction（Qs/Qt）, oxygenation index（OI） and blood lactic acid（BLA） during one-lung ven- tilation（OLV）. [Methods]Twenty eight patients with OLV undergoing open chest operation were chosen and randomly divided into penehyclidine hydrochloride group（group P, aerosolized penehyclidine hydrochloride in- halation during OLV） and control group（group C）. Arterial and mixed venous blood were drawn for blood gas analysis and BLA detection 15min before OLV（T0）, 15min（T~ ） and 45min after OLV（T2 ）. Qs/ Qt and OI were calculated. [Results]After OLV, OI in two groups decreased, but that in group P decreased more slowly than that in group C. Compared with T1 , OI in group P at Tz rose again. After OLV, Qs/Qt and BLA in two groups increased, but that in group P increased more slowly than that in group C. Compared with T1 , Qs/Qt and OI in group P at Tz declined again. [Conclusion]Aerosolized penehyclidine hydrochloride inhalation during OLV can improve oxygenation and decrease intrapulmonary shunt.

关 键 词：肺通气 

分 类 号：R563.9[医药卫生—呼吸系统]