西尼罗病毒及其防治药物研究进展  

West Nile virus and its therapeutic drugs:research advances

作　　者：王志鹏[1] 曾强[1] 宋云龙[1] 

机构地区：[1]第二军医大学药学院药物化学研究室,上海200433

出　　处：《国际药学研究杂志》2013年第4期443-446,459,共5页Journal of International Pharmaceutical Research

基　　金：第二军医大学大学生科研能力创新基金重点项目资助(2012047)

摘　　要：西尼罗病毒为单股正链RNA病毒,属于黄病毒属。人体感染西尼罗病毒可引起西尼罗热、西尼罗脑炎等恶性传染病,严重者可危及生命,但目前缺乏有效的疫苗和治疗药物。因此,开发西尼罗病毒的有效防治药物有着重大意义。本文对西尼罗病毒的生物学特征、流行病学、临床表现、疫苗和治疗药物的研究进展进行综述。West Nile virus is a single stranded RNA virus and belongs to the genus of Flavivirus.Human infections of West Nile virus can cause severe infectious diseases such as West Nile fever and West Nile encephalitis which seriously threaten human life.Up to now,there is still lack of effective vaccines and antiviral drugs against West Nile virus.Therefore,to develop effective drugs for the prevention and treatment of West Nile virus disease is of great importance to protecting human health and maintaining national securities.Herein,the research advances of biological characteristics,epidemiology,clinical symptoms,vaccine and therapeutic drugs of the West Nile virus are reviewed.

关 键 词：西尼罗病毒 生物学特征 流行病学 疫苗 治疗药物 

分 类 号：R373[医药卫生—病原生物学]