芥子气皮肤损伤分子靶标研究进展  

Molecular targets of skin damage for mustard gas:research advances

作　　者：孙培培[1,2] 刘红岩[1] 应莺[1] 陈贤[2] 陆红[2] 钟玉绪[1] 

机构地区：[1]军事医学科学院毒物药物研究所,北京100850 [2]浙江中医药大学药学院,杭州310053

出　　处：《国际药学研究杂志》2013年第4期447-452,共6页Journal of International Pharmaceutical Research

摘　　要：芥子气是一种糜烂性化学毒剂,由于其合成简单,损伤严重,一直是外军的主要化学战剂之一,近年来也成为恐怖活动的主要威胁手段之一,但是由于其作用机制复杂多样,目前还没有特效的抗毒药物,仅能采取防护和对症治疗。为寻找切实有效的特效抗毒药,必须充分了解其作用机制,寻找不同的损伤信号分子。本文就近几年芥子气皮肤损伤的有关信号分子进行综述,以期为新药物的发现提供新思路。Mustard gas[bis-（2-chloroethyl） sulfide]is an erosive chemical agents.Due to its simple synthesis and serious injury,it has been one of the most important chemical warfare agents for foreign military and critical for responding to a terrorist attack,But its mechanism of action is complex and diverse,there are no specific anti-drugs and only to take protective and symptomatic treatment.To find effective specific anti-drugs,it is necessary to fully understand its mechanism of action,and look for different injury signaling molecules.In this paper,damage signaling molecules found in the last few years are summarized so as to provide practical and reliable new methods for the discovery of new drugs.

关 键 词：芥子气 皮肤 分子靶标 

分 类 号：R82[医药卫生—临床医学]