重组人白细胞介素11对卡铂所致猴血小板减少症的治疗作用  

Therapeutic Effects of rhIL-11 on Carboplatin-Induced Thrombocytopenia in Monkeys

作　　者：左从林 徐明波 王勇波 易辉 冯宇霞 李涛 刘秀珍 黄向东 

机构地区：[1]北京双鹭药业有限责任公司,北京双鹭医药生物技术研究所,北京100850 [2]北京昭衍新药研究中心,北京100041

出　　处：《中国实验血液学杂志》2000年第1期31-36,共6页Journal of Experimental Hematology

摘　　要：用卡铂建立的猴骨髓抑制模型观察国产重组人白细胞介素 11(rhIL 11)对血小板减少症的治疗作用。给予模型动物rhIL 115 0或 10 0 μg/kg皮下注射 ,连续 19天。给rhIL 11治疗的猴血小板计数从第 8天开始下降 ,在第 12 - 14天达最低点 ,其下降程度远低于模型动物。rhIL 11治疗后 11- 13天血小板计数开始回升 ,13- 15天达到或超过建立模型前水平 ,停药后血小板数继续升高 ,并维持在高水平。停药 4天后血小板计数开始回落。实验结果证实rhIL 11具有显著的促血小板生成的作用 ,不仅可以缩短卡铂引起的血小板减少症的持续时间 ,而且可以减轻血小板减少症的严重程度。结论提示rhIL 11可作为治疗化疗引起的血小板减少症的有效药物。A model of myelosuppression with thrombocytopenia was produced in monkey by i.v. administration of carboplatin to the evaluate effects of rhIL-11 treatment in monkeys. Following myelosuppression, rhIL-11 was subcutaneously injected for 19 consecutive days at the dose of 50 or 100?μg/kg. In myelosuppressed monkeys treated with rhIL-11, peripheral blood platelet started to drop at the day 8 after the administration of carboplatin, and reaching the nadir between the day 12-14,the decrease in blood platelet was less severe compared with untrea- ted monkeys; peripheral blood platelet began to recovery on day 11-13 (D14-D16)after rhIL-11 treatment, and reached or surpassed the baseline value before carboplatin administration after 13-15 days rhIL-11 treatment. Blood platelet counts remained high level after discontinuation of rhIL-11 administration and returned to baseline after 4 days. The results demonstrated that rhIL-11 has a significant thrombopoietic activity, it can reduce the severity of thrombocytopenia as well as shorten the duration of thrombocytopenia caused by myeloablastive agents, and is likely to become an effective agent against thrombocytopenia induced by chemotherapy.

关 键 词：白细胞介素11 血小板减少症 卡铂 猴 

分 类 号：R392.12[医药卫生—免疫学] R979.5[医药卫生—基础医学]