大黄治疗敌敌畏中毒合并乙醇中毒的临床疗效观察  

Observation on curative efficacy of rhubarb on the treatment of dichlorvos poisoning affiliated with alcohol poisoning

作　　者：周英莲[1] 瞿海龙[1] 张冰[1] 彭广军[1] 梁璐[1] 

机构地区：[1]河北大学附属医院急诊科,河北省保定市071000

出　　处：《职业与健康》2013年第17期2252-2253,共2页Occupation and Health

摘　　要：目的观察大黄治疗急性重度敌敌畏中毒合并乙醇中毒的临床疗效。方法将70例急性重度敌敌畏中毒合并乙醇中毒患者随机分为对照组与治疗组,每组35人,对照组给予常规综合治疗,治疗组在常规治疗基础上,每日给予大黄液100 ml,分2次口服或鼻饲,共用5 d。观察2组患者的病死率、患者从昏迷转为清醒的时间、胆碱酯酶活力上升至正常低限时间、肝功能恢复正常时间、阿托品及氯磷啶用量、住院天数。结果治疗组患者病死率为2.9%,对照组患者病死率为22.9%,2组差异有统计学意义(P<0.05)。治疗组与对照组相比,患者从昏迷转为清醒的时间、胆碱酯酶活力上升至正常低限时间缩短,肝功能恢复加快,阿托品及氯磷啶用量减少,住院时间缩短,2组差异有统计学意义(P<0.05)。结论使用大黄救治急性重度敌敌畏中毒合并乙醇中毒患者具有较好的疗效,值得临床推广使用。[ Objective] To observe the curative efficacy of rhubarb on the treatment of severe acute dichlorvos poisoning affiliated with alcohol poisoning. [ Methods ] 70 cases of severe acute dichlorvos poisoning affiliated with alcohol poisoning were randomly divided into the control group and the treatment group, 35 cases in each group. The control group was treated with routine comprehensive therapy. Oil the basis of the control group, the treatment group was given 100 ml rhubarb liquid （ twice daily ） through oral or nasogastric feeding, for 5 days. The fatality rate, time of consciousness recovery, time of cholinesterase level return to normal lower limit, time of liver function recovery, dose of atropine and prahdoxime iodide, as well as hospitalization days between two groups were compared. [ Results] The fatality rate of the treatment group and the control group was 2.9% and 22.9% respectively, and the difference between two groups was significant （ P 〈 0.05）. Compared with the control group, the time of consciousness recovery,and time of cholinesterase level return to normal lower limit in the treatment group were shorter, liver function recovery was accelerated, dose of atropine and pralidoxime iodide reduced, the hospitalization days was shorter, and there were significant differences between two groups （ P 〈0.05 ）. [ Conclusion] Rhubarb has a better curative effect on the treatment of severe acute dichlorvos poisoning affiliated with alcohol poisoning, and it is worthy of use in clinical practice.

关 键 词：敌敌畏中毒 乙醇中毒 大黄 

分 类 号：R453[医药卫生—治疗学]