综合重症监护病房分离菌分布及其耐药性分析  

Analysis of the distribution and drug-resistance of pathogens in general intensive care unit

作　　者：凃敏[1] 谢红艳[1] 陈英[1] 王华[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院,武汉430030

出　　处：《内科急危重症杂志》2013年第4期214-215,242,共3页Journal of Critical Care In Internal Medicine

摘　　要：目的：了解综合重症监护病房分离茵分布及其耐药性，为经验性抗菌治疗提供依据。方法：我院综合ICU2010年-2012年送检的微生物标本，按微生物常规检测方法进行培养、分离和鉴定，采用K—B纸片扩散法进行药敏实验。结果：综合ICU最常见分离菌为G^-菌（53．5％），G^＋菌占37．5％，真菌占9％，耐苯唑西林金黄色葡萄球菌占金黄色葡萄球菌的66．9％，产超广谱β-内酰胺酶的大肠埃希菌和肺炎克雷伯菌分别为63．8％和30．1％，铜绿假单胞菌和鲍曼不动杆菌中多重耐药菌分别占37．1％和48．4％。结论：综合ICU致病菌多重耐药检出率较高，动态监测分离菌分布及其耐药性，根据药敏谱合理使用抗菌药以及采取有效的院内感染控制措施是当务之急。Objective： To investigate the distribution and drug-resistance of pathogens in general intensive care unit （ICU） in order to provide evidence for empirical antimicrobial therapy. Methods： Methods for microbial routine detection were used to culture, isolate and identify the microbial specimens. The K-B disk diffusion was used to test the drug sensi- bilities of bacterial isolates. Results： The most common pathogens in general ICU were Gram-negative bacteria （53.5%） , followed by Gram-positive bacteria （37.5%） and fungi （9%）. The detection rate of methicillin-resistant staphylococcus aureas （MRSA） was 66.9% , and ESBLs of Escherichia colt and klebsiella pneumonia were 63.8% and 30.1% , respec- tively. Among pseudomonas aeruginosa and acinetobacter baumannii,the multidrug-resistant bacteria accounted for 37.1% and 48.4% ,respectively. Conclusions： The most common pathogens were Gram-negative bacteria in general ICU, the de- tection rate of muhidrug-resistant bacteria were very high. Monitoring the distribution and drug-resistance of bacteria dy- namically, selecting antibiotics reasonably according to the results of antimicrobial susceptibility test and taking effective nosocomial control measures become a major preoccupation for us.

关 键 词：重症监护病房 病原菌 耐药性 

分 类 号：R446.51[医药卫生—诊断学]