原发性高血压病人MAU与颈动脉内膜中层厚度关系  

THE RELATIONSHIP BETWEEN MICROALBUMINURIA IN ESSENTIAL HYPERTENSION AND CAROTID INTIMA-MEDIA THICKNESS

作　　者：马红[1] 马宏[1] 王大鹏[1] 陈以绚[1] 

机构地区：[1]青岛市市立医院干部保健三科,山东青岛266011

出　　处：《青岛大学医学院学报》2013年第5期431-432,435,共3页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：目的探讨原发性高血压(EH)病人微量清蛋白尿(MAU)与颈动脉内膜中层厚度(IMT)的相关性。方法 EH病人92例,按照尿微量清蛋白(UmAlb)水平分为两组,MAU组38例,正常组(NAU组)54例,应用超声检查两组病人颈动脉IMT,并检测尿素氮(BUN)、肌酐(Cr)、尿酸(UA)、三酰甘油(TG)、低密度脂蛋白(LDL-C)和UmAlb水平,进行相关性分析。结果 MAU组病人的尿Cr水平、颈动脉IMT及斑块形成率均高于NAU组,差异有显著性(t=22.598、21.730,χ2=4.165,P<0.05)。EH病人颈动脉IMT与MAU呈正相关(r=0.415,P<0.01)。结论 EH病人MAU水平可能是反映动脉粥样硬化及硬化程度的敏感指标,可作为动脉粥样硬化的一项危险预测因素。Objective To explore the correlation between microalbuminuria （MAU） in patients with essential hyperten- sion （EH） and carotid intima-media thickness （IMT）. Methods Ninety-two EH patients were divided into two groups as MAU group （38 cases） and non-MAU group （54 cases） according to the level of MAU. The carotid IMT of the patients was measured by color Doppler uitrasonography. BUN, Cr, UA, TG, LDL-C, and MAU were detected. A correlation analysis was done. Results The level of Cr, the carotid IMT and formation rate of plaque in MAU group were higher than that in non-MAU group, the diffe- rences being significant between the two groups （t =22.598,21.730;X^2=4.165;P〈0.05）. The IMT was positively correlated with MAU in EH patients （r=0.415 ,P〈0.01）. Conclusion The level of MAU in patients with EH is likely to be a sensitive marker reflecting atherosclerosis and its degree, which can be used to predict the risk factor of the disease.

关 键 词：高血压 颈动脉疾病 清蛋白尿 超声检查 多普勒 彩色 

分 类 号：R544.1[医药卫生—心血管疾病]