急性淋巴细胞白血病病儿血清sCTLA-4测定及意义  

EXPRESSION AND ITS SIGNIFICANCE OF sCTLA-4 IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA

作　　者：王一冰[1] 刘华林[1] 吕富岩[1] 曾鹏[2] 

机构地区：[1]青岛大学医学院附属青岛市妇女儿童医院血液肾脏科,山东青岛266034 [2]青岛大学医学院儿科学教研室

出　　处：《齐鲁医学杂志》2013年第5期399-400,406,共3页Medical Journal of Qilu

摘　　要：目的探讨血清可溶性细胞毒性T淋巴细胞相关抗原-4(sCTLA-4)在急性淋巴细胞白血病(ALL)儿童表达水平及其作用。方法应用ELISA法,检测30例急性B淋巴细胞白血病病儿治疗前及完全缓解6个月后血清sCTLA-4水平,以32例健康体检儿童作为对照。结果 ALL病儿治疗前血清sCTLA-4水平低于对照组,差异有显著性(t=5.236,P<0.01);获得完全缓解后sCTLA-4水平与对照组比较差异无显著性(P>0.05)。不同临床危险度及性别ALL病儿sCTLA-4水平差异无显著性(P>0.05)。结论 ALL病儿治疗前血清sCTLA-4水平降低,可能参与了儿童白血病的发病。Objective To investigate the expression of soluble cytotoxic T lymphocyte antigen-4 （sCTLA 4） molecule in children with acute lymphoblastic leukemia （ALL） and its significance. Methods By using ELISA method, serum level of sCTLA-4 in 30 kids with ALL was detected before therapy and 6 months after complete remission （CR）, and 30 healthy kids served as controls. Results Before therapy, serum sCTLA-4 of the sick kids was lower than that of the controls, the difference was significant （t = 5.236, P 〈 0.01） ; after CR, the difference was not significant between the two groups （P 〉 0.05 ）, and the difference of serum sCTLA-4 between different clinical risk or sex was not significant （P〉0.05）. Conclusion Before therapy, the decrease of serum concentration of sCTLA-4 in kids with ALL is probably due to it involves in the occurrence of this disease.

关 键 词：白血病 淋巴细胞 急性 细胞毒性T淋巴细胞相关抗原-4 儿童 

分 类 号：R725.574[医药卫生—儿科]