男性原发性骨质疏松肾虚三证与性激素变化关系的临床研究  

Relationship between sexual hormones and three types of kidney deficiency in male patients with primary osteoporosis

作　　者：何成奇[1] 熊恩富 孔雅玲[2] 熊素芳 李庭谦 屈云[1] 刘敏[1] 谢微 易文远[1] 邱东生[2] 韩代文 

机构地区：[1]华西医科大学附一院,成都610041 [2]华西医科大学附二院126实验室

出　　处：《中国骨质疏松杂志》2000年第4期50-52,共3页Chinese Journal of Osteoporosis

摘　　要：目的　探讨男性原发性骨质疏松 ( POP)肾虚三证与性激素变化的关系 ,为临床辨证施治提供客观诊断依据。方法　选择 78例有肾虚证的老年男性 POP患者为研究对象 ,平均年龄 63.68± 5.9岁( 56～ 72岁 ) ,其中肾气虚 30例 ,肾阴虚 2 8例 ,肾阳虚 2 0例 ,另选正常对照组 30例 ,平均年龄 64.36± 5.6岁( 56～ 73岁 ) ,同步检测血清 E2 、T、T/ E2 并进行统计学分析。结果　与对照组相比 ,肾虚三型 T、T/ E2 显著下降 ( P<0 .0 5) ,肾虚三型 E2 较对照组显著上升 ( P<0 .0 5) ,肾气虚、肾阳虚、肾阴虚三个证型的血清E2 、T、T/ E2 的性激素水平组间差异显著 ( P<0 .0 5)。逐步判别分析结果表明 :性激素水平可作为 POP肾虚三证的客观诊断指标。结论　 1男性 POP患者性激素 T、T/ E2 的含量变化按肾气虚、肾阳虚、肾阴虚逐渐降低 ,E2 则逐渐升高 ;2男性 POP患者性激素水平变化与肾虚三证关系密切 ,其变化依肾气虚、肾阳虚、肾阴虚逐渐明显 ;3本研究提示性激素水平变化可作为判断男性Objective To provide clinical differentiation of traditional Chinese medicine with objective diagnostic basis by studying the relationship between the change of sexual hormones and three types of kidney deficiency in male patients with primary osteoporosis (POP). Methods Among 78 male patients with kidney deficiency (aged 56-72 years,mean 63.68±5.9 years) 30 had kidney\|qi deficiency,28 kidney\|ying deficiency,and 20 kidney\|yang deficiency;30 normal males without kidney deficiency (aged 56-73 years,mean 64.36±5.6 years) were taken as control group. The levels of serum T,E 2, and T/E 2 were determined simultaneously and analyzed statistically. Results Compared with the control group,the serum T and T/E 2 in the patients with kidney deficiency significantly decreased (P<0.05) while the serum E 2 markedly increased (P<0.05);there was significant difference (P<0.05) in serum T,T/E 2 and E levels among the three types of kidney deficiency in male patients with POP. Discriminant analysis showed that sexual hormones may be taken as objective diagnostic index to determine the three type of kidney deficiency. Conclusions ①The serum T and T/E 2 changes in male patients with POP are gradually decreased,but E 2 increased in the order of kidney\|qi deficiency,kidney\|ying deficiency and kidney\|yang deficiency. ②The changes of serum sexual hormones in male patients with POP are connected closely with the three type of kidney deficiency, and obvious in the increasing order of kidney\|qi deficiency,kidney\|yang deficiency and kidney\|ying deficiency.③The change of sexual hormones levels may be taken as objective diagnostic basis for determining the three types of kidney deficiency in male patients with POP.

关 键 词：性激素 肾虚三证 男性 临床研究 骨质疏松 

分 类 号：R681.02[医药卫生—骨科学] R256.502[医药卫生—外科学]