冠心病伴发高血压病患者PCI后脂质过氧损伤指标的动态变化及临床意义  

Dynamic change and clinical significance of lipid peroxide injury indices after PCI in coronary heart disease patients complicated with hypertension

作　　者：马建林[1] 李斌[1] 张家明[2] 李大主[2] 马立宁[1] 吴忠[1] 陈关良[1] 王圣[1] 张敬文[1] 林劲[1] 王卫[1] 

机构地区：[1]海南省人民医院心内科,海口570311 [2]华中科技大学附属协和医院心内科

出　　处：《临床心血管病杂志》2013年第8期567-569,共3页Journal of Clinical Cardiology

基　　金：海南省卫生厅科研课题(No:琼卫2008-37);海南省自然基金指导性计划项目课题(No:806109)

摘　　要：目的:观察伴发高血压病(HP)的冠心病(CHD)患者行冠状动脉介入术(PCI)治疗后脂质过氧化损伤指标的变化并分析其意义。方法:选择32例CHD患者(A组)及38例CHD伴发HP患者(B组)进行PCI,分别在介入治疗前与治疗后20min、24h及7d采血测定丙二醛(MDA)和超氧化物歧化酶(SOD)水平,并动态随访PCI后冠状动脉病变再狭窄的情况。结果:术后两组患者MDA与SOD水平均较术前有明显变化,脂质过氧化物(LPO)及血管内皮功能指标均有明显变化,但这种变化在B组更加明显;至术后第7天,B组仍有明显变化,而A组已经接近术前水平。结论:CHD患者PCI后出现脂质过氧化损伤指标的变化,这种变化在伴发HP时更加明显,表明CHD患者PCI术后存在明显的氧自由基损伤,而高血压可能促进了这一损伤过程。Objective：To observe the change and significance of lipid peroxide injury indices in coronary heart disease （CHD） patients complicated with hypertension （HP） undergoing percutaneous coronary intervention （PCI）. Method：Thirty-two cases with CHD （group A） and 38 cases with CHD and HP （group B） were chosen to undergo PCI, in which malonaldehyde （MDA） and superoxide dismutase （SOD） were measured before and 20 minutes,24 hours, 7 days after the PCI. The patients were followed up for restenosis of the coronary arteries after PCI. Result：There were significant changes of SOD and MDA in both groups after the PCI, but the changes were even more obvious in group B. There were still changes in group B on the 7th day, whereas the changes were prone to the pre-oprational levels in group A. Conclusion： There are significant changes of lipid peroxide injury indices in CHD patients after PCI, and the changes are even more obvious in the patients complicated with HP. There are significant injury by oxide free radical in CHD patients after PCI, which might be promoted by HP.

关 键 词：冠心病 高血压 经皮冠状动脉介入术 脂质过氧化损伤 

分 类 号：R541.4[医药卫生—心血管疾病]