高血压患者血浆脂蛋白相关磷脂酶A2与左心室肥厚的关系  

Relationship between lipoprotein-associated phospholipase A2 and left ventricular hypertrophy in patients with essential hypertension

作　　者：李帅兵[1] 赵洛沙[1] 杨帆[1] 荆莉[1] 马娟[1] 贾亚丹[1] 董少英[1] 郑卫峰[1] 

机构地区：[1]郑州大学第一附属医院心内科,郑州450052

出　　处：《临床心血管病杂志》2013年第8期577-579,共3页Journal of Clinical Cardiology

摘　　要：目的:探讨原发性高血压患者血浆脂蛋白相关磷脂酶A2(Lp-PLA2)与左心室肥厚的关系。方法:选择183例原发性高血压患者,采用超声心动图测其舒张末期左心室内径(LVDD)、室间隔厚度(IVST)及左心室后壁厚度(LVPWT),计算左心室质量指数(LVMI),按LVMI≥125g/m2(男)或LVMI≥120g/m2(女)将患者分为左心室肥厚组(LVH组,120例)组及非左心室肥厚组(非LVH组,63例),用ELISA方法测定各组Lp-PLA2浓度。所有患者均测定或计算BMI、高血压病程、收缩压(SBP)、舒张压(DBP)、尿酸(UA)、高敏C反应蛋白(hs-CRP)、TC、LDL-C、LVMI及Lp-PLA2浓度等,并进行相关性和回归分析。结果:与非LVH组比较,LVH组Lp-PLA2浓度显著增加(P<0.05);Pearson相关分析显示,Lp-PLA2与BMI、TC、HDL-C、LDL-C及hs-CRP均呈正相关(均P<0.05),LVMI与BMI、高血压病程、SBP、DBP、UA、hs-CRP及Lp-PLA2均呈正相关(均P<0.05);多元逐步回归分析显示,LVMI与高血压病程、SBP及Lp-PLA2呈正相关(均P<0.05),与BMI、DBP、UA及hs-CRP无相关性。结论:Lp-PLA2与左心室肥厚具有独立正相关性,Lp-PLA2在一定程度上反映了左心室肥厚的发生。To investigate the relationship between lipoprotein-associated phospholipase A2 （Lp-PLA2） and left ventricular hypertrophy （LVH） in patients with essential hypertension （EH）. Method： We documented 183 consecutive essential hypertensive patients. Left ventricular end-diastolic diameter （LVDD）, interventricular seprum thickness （IVST） and left ventricular posterior wall thickness （LVPWT） were measured by echocardiography and left ventricle mass index （LVMI） was calculated. According to left ventricular hypertrophy （male LVMI^125 g/m2, female LVMI≤120 g/m^2）, all patients were further divided into LVH group （n= 120） and non-LVH group （n=63） to elucidate the influence of Lp-PLA2 on LVH. The plasma Lp-PLA2 concentration was measured by ELISA method. Result： Compared with non-LVH group, Lp-PLA2 concentration significantly increased in LVH group （P〈0.01）. Pearson correlation analysis showed that Lp-PLA2 was positively correlated with BMI, TC, LDL-C and hs-CRP （all P〈0.05）, and LVMI was positively correlated with BMI, the course of EH, SBP, DBP, UA, hs-CRP and Lp-PLA2 （all P〈0.0 05）. Multiple stepwise regression analysis revealed that Lp-PLA2 significantly and independently correlated with LVML Conclusion： Lp-PLA2 concentration is positively correlated with LVHI and could be a risk factor for LVH in patients with EH.

关 键 词：高血压 血浆脂蛋白相关磷脂酶A2 左心室肥厚 

分 类 号：R544.1[医药卫生—心血管疾病]