遗传及相关因素与稽留流产关系的研究进展  

Advances in the Study of Genetic and Environmental Factors in Missed Abortion

作　　者：杜晶[1] 张兆奉[1] 徐建华[1] 

机构地区：[1]国家卫生与计划生育委员会计划生育药具重点实验室、上海市计划生育科学研究所,上海200032

出　　处：《生殖与避孕》2013年第8期552-556,共5页Reproduction and Contraception

摘　　要：稽留流产是妇产科一种常见病,导致稽留流产的病因包括遗传和环境等因素,但确切机制尚不明确。众多研究表明,稽留流产病因复杂,与p53、MDM2或HDM2及ER等相关基因多态性及Fas/FasL系统、Fas相关死亡结构域蛋白、Livin、survivin、bax、caspase、HIF及AAH等基因表达异常有关;另外环境因素包括化学物质、物理因素(如放射线、噪音及高温等)以及不良生活习惯(如吸烟、饮酒、吸毒、过多使用电脑、手机、生活不规律及职业紧张等)均可引起稽留流产。因此从遗传和环境两方面来进一步研究其发生发展机理,可以更好地给临床实践提供指导。Missed abortion is a common obstetric disease and it is a multifactorial disorder, both genetic and environmental factors contribute to the development of missed abortion. But the exact mechanism is unclear. Numerous studies have shown that etiologies of missed abortion are complex. Known etiologies of missed abortion include mutations of p53, MDM2 （HDM2） and ER gene, abnormal expression of Fas/FasL system, FADD, Livin, surviving, bax, caspase, HIF and AAH gene. Environmental factors include chemicals, physical factors （radioactive rays, noise and high temperature, etc.） and unhealthy living habits （smoking, drinking, taking drugs, using computers and mobile phone often, irregular life and great work pressure, etc.）. So studying the mechanism of missed abortion according to the genetic and environmental factors is very important for guiding clinical practice.

关 键 词：遗传因素 环境因素 稽留流产 

分 类 号：R714.21[医药卫生—妇产科学]