内源性大麻素系统在胃肠道的作用(英文)  

Role of endogenous cannabinoid system in the gut

作　　者：林旭红[1,2] 王亚强[2] 王慧超[3] 任学群[4] 李永渝[1] 

机构地区：[1]同济大学医学院病理生理教研室、同济大学消化系疾病研究所,上海200092 [2]河南大学淮河医院检验科,开封475000 [3]河南大学一附院肾内科,开封475000 [4]河南大学淮河医院普外科,开封475000

出　　处：《生理学报》2013年第4期451-460,共10页Acta Physiologica Sinica

基　　金：supported by the National Natural Science Foundation of China(No.81141050,81270477)

摘　　要：植物大麻用于临床已有几千年的历史,在许多胃肠道疾病如呕吐、腹泻、炎症性肠病、肠源性疼痛治疗中发挥重要作用。本文旨在综述内源性大麻素系统的组成及其在胃肠道活动中的调节作用,为进一步研究提供相关信息,并为通过调节胃肠道内源性大麻素系统治疗胃肠道疾病提供新靶点。The plant Cannabis has been used in clinic for centuries, and has been known to be beneficial in a variety of gastrointestinal diseases, such as emesis, diarrhea, inflammatory bowel disease and intestinal pain. In this text, we＇ll review the components of the endogenous cannabinoid system as well as its role in the regulation of gastrointestinal activities, thus providing relative information for further study. Moreover, modulation of the endogenous cannabinoid system in gastrointestinal tract may provide a useful therapeutic target for gastrointestinal disorders.

关 键 词：大麻素 内源性大麻素系统 大麻素受体 内源性配体 胃肠道功能 

分 类 号：R96[医药卫生—药理学]