载脂蛋白B基因XbaI多态性与胆石症关系的Meta分析  

Meta-analysis for association between XbaI polymorphism of apolipoprotein B gene and cholelithiasis

作　　者：刘照国 刘雷 卢海明 张其顺 

机构地区：[1]广西柳州市工人医院肝胆外科,广西柳州545005

出　　处：《中国普通外科杂志》2013年第8期1011-1015,共5页China Journal of General Surgery

摘　　要：目的:通过Meta分析比较载脂蛋白B(ApoB)基因XbaI位点等位基因与基因型的分布频率,探讨ApoB基因XbaI多态性与胆石症的关系。方法:全面检索收集ApoB基因XbaI多态性与胆石症的有关研究文献。对各研究结果应用CMA2.0软件以Meta分析的方法进行数据合并,并评价合并值的发表偏倚。结果:符合纳入标准的相关文献13篇,其中胆石症组1 672例,对照组1 923例。Meta分析结果显示,在亚洲人群中,X+等位基因在胆石症组的分布频率明显高于对照组(OR=2.76,95%CI=2.12-3.59),而X-X-基因型在胆石症组的分布频率明显低于对照组(OR=0.35,95%CI=0.27-0.47)(均P<0.05)。发表性偏倚检验显示不存在发表偏倚,稳定性较好。结论:亚洲人群中胆石症的发生与ApoB基因XbaI多态性有关,等位基因X+可能是胆石症的危险因素,基因型X-X-可能是胆石症的保护因子。Objective：To investigate the relationship between XbaI polymorphism of apolipoprotein B（ApoB） gene and cholelithiasis through comparison of the allele and genotype distribution frequencies at XbaI site of ApoB gene by Meta-analysis.Methods：A literature search was performed regarding the relation of XbaI polymorphism of ApoB gene with gallstone.All trial data were combined and analyzed according to the Meta-analysis methodology using CMA2.0 software,and the publication bias of pooled studies was also assessed.Results：Thirteen related studies that met the inclusion criteria were selected,with 1 672 cases in gallstone group and 1 923 subjects in control group.The results of Meta-analyses showed that in Asian population,the frequency of X＋ allele was significantly increased（OR=2.76,95% CI=2.12–3.59）,but the frequency of X–/–genotype was significantly decreased in gallstone group compared with control group（OR=0.35,95% CI=0.27–0.47）（both P＆lt;0.05）.Assessment found no evidence of publication bias that confirmed stability of this Meta-analysis.Conclusion：XbaI polymorphism of ApoB gene is associated with gallstone occurrence among Asians,in which the X＋ allele is a risk factor and the g X–/–genotype is a protective factor.

关 键 词：胆结石 载脂蛋白B类 多态现象 遗传 META分析 

分 类 号：R657.4[医药卫生—外科学]