QT间期延长与药物安全性评价  

Prolongation of QT Interval and Evaluation of Safety of Drugs

作　　者：李妍[1] 徐晶[1] 张文胜[1] 

机构地区：[1]四川大学华 西医院转化神经科学中心麻醉与危重急救研究室,成都610041

出　　处：《生物医学工程学杂志》2013年第4期905-908,共4页Journal of Biomedical Engineering

摘　　要：药物引发的QT间期延长因可导致致命性的心律失常而受到广泛关注。本文介绍了QT间期延长的发生机制、危险因素以及其指导原则,综述了因QT间期延长导致的药物撤市,并探讨了QT间期在新药安全性评价中的价值。People pay more and more attention to the prolongation of QT interval caused by drugs because it could probably result in lethal arrhythmia. This article introduces mechanisms, risk factors and guidelines for QT interval, and also reviews drugs withdrawal from the market due to the results of prolongations of QT interval. It discusses as well the value of new drugs in the QT interval for the evaluation of safety.

关 键 词：QT间期延长 心律失常 危险因素 药物评价 

分 类 号：R969[医药卫生—药理学]