藏药“五味麝香丸”药效学实验研究  

Experimental Study on the Pharmacodynamics of Tibetan Drug“WuWei SheXiang Pill”

作　　者：贡布东智 阿召 何强 任远[3] 马骏[3] 吴国泰[3] 

机构地区：[1]甘南州藏医药研究院,甘肃甘南747000 [2]甘南佛阁藏药有限公司 [3]甘肃中医学院

出　　处：《西部中医药》2013年第8期55-57,共3页Western Journal of Traditional Chinese Medicine

摘　　要：目的:观察五味麝香丸对模型动物的抗炎镇痛作用。方法:制造大鼠、小鼠炎症模型和疼痛模型,观察五味麝香丸的抗炎镇痛作用。结果:五味麝香丸0.021 g/kg和0.010 g/kg两个剂量对组织胺所致大鼠足趾肿胀有明显抑制作用,与对照组相比差异有统计学意义(P<0.05);五味麝香丸0.030g/kg和0.015g/kg两个剂量组对二甲苯所致小鼠耳壳肿胀和冰醋酸所致小鼠腹腔毛细血管通透性增加有明显抑制作用,与对照组相比差异有统计学意义(P<0.05)。五味麝香丸0.030 g/kg和0.015 g/kg两个剂量组对冰醋酸所致小鼠扭体反应有明显抑制作用,与对照组相比差异有统计学意义(P<0.01);五味麝香丸0.030 g/kg剂量组对小鼠热板痛阈值有明显提高作用,其作用在给药后60分钟和90分钟时较明显,与对照组相比差异有统计学意义(P<0.05)。结论:五味麝香丸具有明显的抗炎和镇痛作用。Objective： To explore the anti-inflammation and analgesia actions of WuWei SheXiang pills on the animal models.Method： The rats and mice models suffering from inflammation and pain were established through observing the effects of WuWei SheXiang pills.Result： WuWei SheXiang pills showed the inhibition to toe swollen induced by histamine at the doses of 0.021g/kg and 0.010 g/kg obviously,the difference had statistical meaning compared with the control group（P〈0.05）;it also could inhibit ear-swollen caused by dimethylbenzene and the increase of capillary vessel permeability induced by glacial acetic acid remarkably at the doses of 0.030g/kg and 0.015g/kg,the differences had statistical meaning compared with the control group（P〈0.05）.The results of analgesia tests demonstrated that the drug could also inhibit the writhing test of the mice induced by acetic acid at the doses of 0.030 g/kg and 0.015 g/kg,the differences had statistical meaning compared with the control group（P〈0.01）;it could improve hot-plate threshold of the mice at the dose of 0.030 g/kg,it took effects in 60 minutes and 90 minutes after medication notably,the differences had statistical meaning compared with the control group（P〈0.05）.Conclusion： WuWei SheXiang pills show the function of better anti-inflammation and analgesia.

关 键 词：五味麝香丸 抗炎 镇痛 大鼠 小鼠 

分 类 号：R285.5[医药卫生—中药学]