人脑GABA测量在临床3T磁共振成像系统上的实现  

Detection of GABA in Human Brain on Clinical 3T MRI Scanner

作　　者：陈录广[1] 李建奇[1] 王前锋[1] 

机构地区：[1]华东师范大学物理系,上海市磁共振重点实验室,上海200062

出　　处：《波谱学杂志》2013年第3期345-353,共9页Chinese Journal of Magnetic Resonance

基　　金：上海市科委基础研究重点资助项目(10JC1414600);国家自然科学基金资助项目(81271533)

摘　　要：γ-氨基丁酸(γ-Aminobutyric Acid,GABA)是人脑中枢神经系统中一种重要的抑制性神经递质,对神经活动的调节起着主导作用.由于人脑GABA固有含量低以及与其他代谢物谱峰的重叠,在临床用磁共振成像系统中使用点分辨波谱(PRESS)序列或受激回波采集模式(STEAM)序列难以直接检测到GABAδ3.01信号.该文报道了MEGA-PRESS脉冲序列在临床用3T磁共振成像系统上的实现,采用J差分谱编辑技术实现了对GABA的检测.水模实验和人脑在体实验显示,MEGA-PRESS序列对GABAδ3.01信号具有较好的检测效果.GABA （γ-aminobutyric acid） is a major inhibitory neurotransmltter m the cen- tral nervous system of human brain, and plays a predominant role in the regulation of neuronal activity. Detection of GABA by in vivo magnetic resonance spectroscopy is hindered by its inherent low concentration and overlapping with resonances from other metabolites. GABA cannot be directly detected with the PRESS （point resolved echo spectroscopy） or STEAM （stimulated echo acquisition mode） pulse sequences on the clinical MRI scanners. This paper reported the implementation of a single-voxel spectroscopy J-difference editing sequence （MEGA-PRESS） for detection of GABA. The resuits from phantom studies and human brain indicated that it is feasible to use MEGAPRESS for detection of GABA on 3 T clinical MRI scanners.

关 键 词：γ-氨基丁酸(GABA) J差分 谱编辑 MEGA-PRESS 

分 类 号：O482.53[理学—固体物理]