杀菌剂噻呋酰胺的合成工艺研究  

Study on the synthetic process of fungicide Thifluzamide

作　　者：崔凯[1] 马洁洁[1] 丁志远[1] 于海燕[1] 曹淼倩[1] 丁海霞[1] 

机构地区：[1]南京大学金陵学院化学与生命科学学院,江苏南京210089

出　　处：《应用化工》2013年第8期1454-1456,1460,共4页Applied Chemical Industry

摘　　要：以4,4,4-三氟乙酰乙酸乙酯为原料,经氯化、环合、酰化得到噻呋酰胺。通过采用无溶剂法、中间体不提纯法、溶剂归一化法优化工艺,并考察敷酸剂、相转移催化剂的种类等因素对产量、纯度的影响。在优化的反应条件下,噻呋酰胺粗品含量大于98%。An improved synthesis process of Thifluzamide,an important agrochemical intermediate,which came from ethyl trifluoroacetoacetate was described.Using solvent-free process,non-purification intermediates method,unified solvent method to optimize the process,and the types of acid binding agent and phase transfer catalyst were investigated so as to determine the best of the technological parameters.Under the optimal reaction conditions,Thifluzamide crude purity was up to 98%.

关 键 词：杀菌剂 噻呋酰胺 三氟乙酰乙酸乙酯 合成 

分 类 号：TQ455.4[化学工程—农药化工]