一锅法合成5,6-二苯基-4-对甲苯基-3,4-二氢嘧啶-2-酮工艺研究  

Study of synthesis technology of 5,6-diphenyl-4-p-tolyl-3,4 dihydropyrimidin-2(1H)-ketone by one-pot method

作　　者：闫杏丽[1] 陈天云[1] 

机构地区：[1]合肥工业大学化学工程学院,安徽合肥230009

出　　处：《合肥工业大学学报（自然科学版）》2013年第8期993-995,共3页Journal of Hefei University of Technology：Natural Science

摘　　要：文章以二苯乙酮、对甲基苯甲醛和尿素为原料,在催化剂的作用下合成了5,6-二苯基-4-对甲苯基-3,4-二氢嘧啶-2-酮。通过实验确定了反应的较佳工艺参数如下:二苯乙酮、对甲基苯甲醛、尿素的摩尔比为1∶1.15∶1.1,反应温度为80℃,反应时间为2.0h,催化剂选用NaOC2H5,其用量为0.001mol,在该工艺条件下,产物的收率达到了96%。采用FT-IR和1 HNMR对目标化合物的结构进行了表征。In the presence of a catalyst, 5, 6-diphenyl-4-p-tolyl-3, 4-dihydropyrimidin-2 （1H）_ketone were synthetized by acetophenone, p-methylbenzaldehyde and carbamide which were used as raw ma- terials. The experimental results showed that when the molar ratio of acetophenone, p-methylbenzal- dehyde and carbamide was 1 1.15 ： 1.1, the reaction temperture was 80 ℃, the reaction time was 2. 0 h, and the amount of substance of NaOC2H5 used as the catalyst is 0. 001 tool, the product yield could reach 96%. The structure ofthe product was confirmed by FT-IR and 1HNMR.

关 键 词：5 6-二苯基-4-对甲苯基-3 4-二氢嘧啶-2-酮 二苯乙酮 对甲基苯甲醛 尿素 合成工艺 

分 类 号：TQ224.7[化学工程—有机化工]