系统性硬化症相关性肺动脉高压的临床特点  

Clinical characteristics of systemic sclerosis-associated pulmonary arterial hypertension

作　　者：曾大雄[1] 王昌国[1] 黄建安[1] 

机构地区：[1]苏州大学附属第一医院呼吸内科,江苏苏州215006

出　　处：《临床肺科杂志》2013年第10期1747-1749,共3页Journal of Clinical Pulmonary Medicine

基　　金：国家自然科学基金(No.81100038)

摘　　要：目的探讨系统性硬化症(SSc)合并肺动脉高压(PAH)的发病率、临床特点及评估指标。方法分析本院确诊的18例系统性硬化症合并肺动脉高压的患者临床资料和诊治过程,并以同期确诊的系统性硬化症(未合并肺动脉高压)患者作为对照。结果两组患者在性别比和年龄上并无统计学差异。但SSc合并PAH组(SSc-PAH)患者在肺动脉收缩压(sPAP)、雷诺现象发生率、肺间质性改变发生率等方面明显高于SSc组。此外,SSc-PAH组患者的RNP抗体阳性率、IgG水平显著高于对照组。结论雷诺现象、肺间质性改变、RNP抗体、血清IgG水平与SSc患者合并PAH密切相关。这类患者应及早行心超检查,以求早期诊治,改善预后。Objective To observe the features of of systemic sclerosis-associated pulmonary arterial hypertension （SSc-PAH）, including prevalence, clinical characteristics and evaluation markers. Methods The clinical data and therapy process of 18 patients with SSc-PAH in our hospital from 2009 to 2012 were retrospectively analyzed. At the same time, they were compared with SSc patients without PAH as the controls. Results There was no obvious difference on sexuality and age between the two groups. But there were significant differences on sPAP, incidence of Ranaud~ phenomenon and pulmonary interstitial changes between the two groups. Besides, the positive rate of BNP antibody and the serum level of IgG were significantly higher in the SSc-PAH group than in the control group. Conclusion The SSc patients complicated with PAH are closely correlated with Raynaudg phenomenon, pulmonary interstitial changes and serum IgG level. The patients with these features should be checked by the doppler eehoeardiography and given early treatment to improve their prog-nosis.

关 键 词：系统性硬化症 肺动脉高压 临床特点 

分 类 号：R593.2[医药卫生—内科学]