肿瘤标记物在特发性肺间质纤维化中的临床意义  

Clinical significance of tumor markers in idiopathic pulmonary fibrosis

作　　者：徐凌[1] 边巍[1] 顾杰[1] 杨丹榕[1] 容朝晖[1] 沈策[1] 

机构地区：[1]上海交通大学附属第六人民医院呼吸科,上海200233

出　　处：《临床肺科杂志》2013年第10期1865-1867,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的探讨肿瘤标记物在特发性肺间质纤维化(IPF)中的临床意义。方法分析57例IPF患者及713例其他肺病患者的临床资料。结果 IPF患者血清中多种肿瘤标记物升高,血清CYFRA21-1与DLCO(r=-0.608,P=0.013)、PaO2(r=-0.487,P=0.000)呈显著负相关,与P(A-a)O2呈显著正相关(r=0.433,P=0.002),CA125与PaO2(r=-0.374,P=0.042)、CA19-9与DLCO呈显著负相关(r=-0.518,P=0.016)。结论 IPF患者血清中许多肿瘤标记物升高,其中CYFRA21-1、CA19-9、CA125与疾病严重性相关,CYFRA21-1还与预后相关,是预后不良的标志。Objective To explore the clinical significance of tumor markers in idiopathic pulmonary fibrosis （IPF）. Methods The clinical data of 57 patients with IPF and 605 patients with other benign lung diseases were retrospectively analyzed. Results The lev- els of CA19-9, CA15-3, CA72-4, CEA and CYFRA21-1 in serum were significantly higher in patients with IPF than those with benign lung diseases. The level of CYFRA21-1 was negatively correlated with the levels of DLCO and PaO2 （rI = -0. 608, P1 =0. 013 and r2 = -0. 487, P2 =0. 000 respectively） , and it was positively correlated with P（A-a） 02 （ r =0. 433, P =0. 002）. The level of CA125 was negatively correlated with the level of PaO2 （r = -O. 374, P = 0. 042 ） , and the level of CA19-9 was negatively correlated with DLCO （r = -0. 518, P = 0. 016）. Logistic regression analysis showed CYFRA21-1 was an independent predictor for mortality in IPF patients. Conclusion Many tumor markers arc elevated in serum of IPF patients. Among these markers, CYFRA21-1, CA19-9, and CA125 seems to be useful markers to indicate the severity of the diseases. CYFRA21-1 is also useful in the prediction of prognosis in IPF patients.

关 键 词：特发性肺间质纤维化 肺癌 肿瘤标记物 

分 类 号：R563.9[医药卫生—呼吸系统]