治疗糖尿病肾病新药的临床研究现状  

Current status of clinical research on novel treatment of diabetic nephropathy

作　　者：刘沫言[1,2] 朱晗玉[1] 蔡广研[1] 陈香美[1] 

机构地区：[1]解放军总医院肾脏病科肾脏疾病国家重点实验室,北京100853 [2]济南军区总医院肾病科

出　　处：《中华肾病研究电子杂志》2013年第1期41-46,共6页Chinese Journal of Kidney Disease Investigation（Electronic Edition）

摘　　要：糖尿病肾病(DN)是糖尿病的严重并发症之一,是发达国家终末期肾病的首要原因。近些年,基于几项大型的、等级强度高的随机对照试验对目前DN的治疗提出了新的挑战,涌现出一系列治疗DN的"新药"。基于循证医学的角度,针对DN发病机制的治疗靶点,有必要对近年治疗DN的一些较有争议的新药物进行综述。Diabetic nephropathy （DN） is one of the serious complications of diabetes, and is the leading cause of end-stage renal disease in developed countries. In recent years, based on several large- scale, randomized controlled trials, treatment of DN is facing new challenges. ＂Novel drugs＂ have been successively applied to the treatment of DN. Here, we have reviewed the new progress of DN treatment in recent years according to the evidence-based medicine combined with the therapeutic targets of DN.

关 键 词：慢性肾脏病 糖尿病肾病 终末期肾病 随机对照试验 

分 类 号：R587.2[医药卫生—内分泌]