Activities of a Novel Phenanthrene Imine to Kill Tumor Cells  

作　　者：WANG Xu-dong JIN Li-min SUN Zhi LI Dong-ni LIU Tie-mei 

机构地区：[1]The Second Hospital of Jilin University, Changchun 130041, P. R. China [2]The First Hospital of Jilin University, Changehun 130021, P. R. China [3]China-Japan Union Hospital, Jilin University, Changchun 130033, P. R. China

出　　处：《Chemical Research in Chinese Universities》2013年第4期721-723,共3页高等学校化学研究（英文版）

摘　　要：A novel phenanthrene imine was synthesized from 9,10-phenanthrenequinone, 1,4-diazabicyclo octane （Dabco）, 2,6-dimethylaniline, 2,6-diisopropylaniline and TIC14 via standard Schlenk and vacuum-line or glovebox techniques. 3-（4,5-Dimethylthiazolyl-2）-2,5-diphenyltetrazolium bromide（MTT） assay and flow cytometry（FCM） were used to detect the activities of the compound to kill tumor cells and the mechanisms of action were investigated in the study. The results show that the compound is active in killing tumor cells. Mechanistic investigations found that the compound could induce apoptosis of tumor cells.A novel phenanthrene imine was synthesized from 9,10-phenanthrenequinone, 1,4-diazabicyclo octane （Dabco）, 2,6-dimethylaniline, 2,6-diisopropylaniline and TIC14 via standard Schlenk and vacuum-line or glovebox techniques. 3-（4,5-Dimethylthiazolyl-2）-2,5-diphenyltetrazolium bromide（MTT） assay and flow cytometry（FCM） were used to detect the activities of the compound to kill tumor cells and the mechanisms of action were investigated in the study. The results show that the compound is active in killing tumor cells. Mechanistic investigations found that the compound could induce apoptosis of tumor cells.

关 键 词：9 10-Phenanthrenequinone Phenanthrene imine Tumor killing Apoptosis 

分 类 号：TQ522.64[化学工程—煤化学工程] Q279[生物学—细胞生物学]