山楂消脂胶囊对代谢综合征并颈动脉硬化患者斑块稳定性的影响  

Effect of Shanzha Xiaozhi Capslue on Stability of Atherosclerosis Plaques in Patients with Metabolic Syndrome and Carotid Atherosclerosis

作　　者：杨红蕾[1] 王文会[1] 赵华云[1] 陈伟强[1] 刘照宏[1] 梁彤[1] 

机构地区：[1]佛山市中医院,广东佛山528000

出　　处：《中国中医药信息杂志》2013年第9期10-12,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：佛山市卫生局医学科研项目(2012153)

摘　　要：目的观察山楂消脂胶囊对代谢综合征(MS)并颈动脉硬化(CAS)患者斑块稳定性的影响。方法将符合诊断标准的106例MS并CAS患者随机分为2组。对照组51例予改善生活方式并控制好相关危险因素,治疗组55例在对照组基础上加用山楂消脂胶囊,疗程6个月。观察心脑血管事件的发生率,比较治疗前后2组患者颈动脉内膜-中层厚度(IMT)和斑块分级,并测定治疗前后超敏C反应蛋白(Hs-CRP)、同型半胱氨酸(Hcy)、胰岛素抵抗指数(HOMA-IR)的变化。结果治疗组急性心脑血管事件发生率较对照组降低(P=0.047),治疗组颈动脉IMT和斑块分级与对照组比较明显降低(P<0.05),同时治疗组可明显降低Hs-CRP、Hcy、HOMA-IR,与对照组比较差异有统计学意义(P<0.01)。结论山楂消脂胶囊可减轻颈动脉IMT和斑块积分,稳定动脉粥样硬化斑块,从而减少急性心脑血管事件的发生。Objective To investigate the effect of Shanzha Xiaozhi Capslue on stability of atherosclerosis plaques in patient with metabolic syndrome （MS） and carotid atherosclerosis （CAS）. Methods Totally 106 patients with MS and CAS were randomly divided into 2 groups with 55 cases in the treatment group and 51 cases in the control group. The control group improved the way of life and control of relevant risk factors, while the treatment group was treated with Shanzha Xiaozhi Capslue additionally for 6 months. The occurrence of major adverse cardiovascular and cerebrovascular events of the two groups was compared. The intima-media thickness, plaques grade of carotid artery and the changes of Hs-CRP, Hcy, insulin resistance were measured before and after the treatment. Results After treatment, the occurrence of major adverse cardiovascular and cerebrovascular events in the treatment group reduced significantly compared with the control group （P =0.047）. The intima-media thickness and plaques grade of carotid artery in the treatment group decreased significantly compared with the control group （P〈0.05）, and the serum levels of Hs-CRP, Hcy, insulin resistance were decreased significantly compared with the control group （P〈0.01）. Conclusion Shanzha Xiaozhi Capslue can decrease the intima-media thickness and plaques score of carotid artery, stabilize atherosclerotic plaque, thus reduce the occurrence of major adverse cardiovascular and cerebrovascular events of patients with MS and CAS.

关 键 词：山楂消脂胶囊 代谢综合征 颈动脉硬化 颈动脉内膜-中层厚度 斑块稳定性 

分 类 号：R259.89[医药卫生—中西医结合] R259.435[医药卫生—中医内科学]