氯沙坦治疗慢性肾功能不全伴高血压20例观察  

Effects of Losartan on Treatment of Chronic Renal Impairment

作　　者：谢燕[1] 李声宏[1] 顾振纶[2] 

机构地区：[1]苏州大学附属一院肾内科,苏州215006 [2]苏州大学基础医学部

出　　处：《苏州医学院学报》2000年第9期822-824,共3页Acta Academiae Medicinae Suzhou

摘　　要：目的　评价氯沙坦在治疗慢性肾功能不全伴高血压时对肾脏的保护作用。方法　 40例慢性肾功能不全伴高血压患者 ,2 0例接受氯沙坦 (Los)治疗 ,2 0例接受苯那普利 (Ben)治疗 ,对照观察 4周。治疗前后测血压、肾功能、内生肌酐清除率、2 4h尿蛋白定量。结果　Los与Ben组的降压有效率分别为 95 %、90 % ,但差异无显著性(P >0 .0 5 )。两组治疗前后血清肌酐、尿素氮及内生肌酐清除率均无明显变化。氯沙坦可降低血尿酸水平 ,与治疗前对照有显著差异 (P <0 .0 1) ;苯那普利不影响血清尿酸。两组治疗后 2 4h尿蛋白均较治疗前减少 (P <0 .0 5 )。氯沙坦不良反应轻微。结论　氯沙坦对高血压患者慢性肾功能代偿与失代偿期有效 ,且副作用小 ,与利尿剂合用其降压效果可增强 ;氯沙坦有肾脏保护作用。Objective To evaluate the renal protective effects of losartan in treatment of chronic renal impairment.Methods Forty patients were divided into two groups:20 patients treated with losartan (50mg,qd),20 patients treated with benazepril (10mg,qd),all groups were treated for 4 weeks.Blood pressure,renal function,creatinine clearance and the protein excretion rates were examined before and after therapy.Results According to blood pressure measurment the overall efficacy rate of losartan and benazepril was 95% and 90% respectively.No statistical singnificant difference between two groups was found ( P >0.05).Creatinine clearance,blood creatinine and uria nitrogen were not increased in losartan and benazepril groups.Losartan had an effect on decreasing urine acid after the therapy ( P <0.05),while benazepril had no effect.Fixed quantity of urinary protein in 24 hours decreased after the therapy in both groups ( P <0.05).The adverse reaction of losartan was mild.Conclusion Losartan is effective and safe in treatment of mild and moderate chronic renal impairment.It reveals synergistic action when used with uragogue.Losartan has a good renal protective effect.

关 键 词：氯沙坦 高血压 慢性肾功能不全 

分 类 号：R692.506[医药卫生—泌尿科学] R544.105[医药卫生—外科学]