中西医结合治疗2型糖尿病疗效及安全性分析  

Efficacy and Safety of Integrated Chinese and Western Medicine Treatment for Type 2 Diabetes Mellitus

作　　者：雷长国[1] 张继华[1] 蔡林[2] 

机构地区：[1]黔南民族医学高等专科学校民族医药系,贵州都匀558003 [2]川北医学院附属医院中医科,四川南充637000

出　　处：《广州中医药大学学报》2013年第5期624-627,共4页Journal of Guangzhou University of Traditional Chinese Medicine

摘　　要：【目的】评价养阴清热经验方合二甲双胍治疗2型糖尿病阴虚热盛证的临床疗效及安全性。【方法】将100例2型糖尿病阴虚热盛证患者随机分为联合治疗组(观察组)60例和二甲双胍组(对照组)40例。对照组口服二甲双胍0.5 g/次,每日3次;观察组在对照组用药的基础上加服养阴清热经验方水煎剂,每日1剂,分2次温服。2组在治疗过程中均严格控制饮食,2组疗程均为8周。观察2组患者治疗前后主要症状、体征,空腹血糖(FPG)、餐后2 h血糖(2hPG)等糖代谢指标和总胆固醇(TC)、甘油三酯(TG)等脂代谢指标的变化情况,评价其中医临床症候疗效和安全性。【结果】(1)观察组的总有效率为96.67﹪,对照组为77.50﹪。观察组的中医临床症候疗效优于对照组(P<0.05)。(2)治疗后2组FPG、2hPG等糖代谢指标和TC、TG等脂代谢指标均有明显改善,与治疗前比较差异均有统计学意义(P<0.05或P<0.01),且观察组的改善作用明显优于对照组(P<0.05或P<0.01)。(3)在治疗过程中,观察组出现的不良反应明显少于对照组(P<0.01)。【结论】养阴清热经验方合二甲双胍是治疗2型糖尿病阴虚热盛证安全可靠而有效的方法。Objective To evaluate the clinical efficacy and safety of Metformin plus self-prescribed Chinese herbal recipe for nourishing yin and clearing heat, Yaagyin Oingre Recipe, in treating type 2 diabetes mellitus （T2DM） with yin deficiency and excessive heat syndrome. Methods One hundred T2DM patients with yin deficiency and excessive heat syndrome were randomly divided into two groups of observation group （N= 60） and control group （N=40）. Both groups were given oral use of metformin, 0.5 g every time, 3 times a day, and the observation group was treated with the decoction of Yangyin Qingre Recipe orally, one dose a day, administration for twice. Both groups followed strict dietary control during the treatment, and the treatment lasted 8 weeks. The main symptoms and signs, fasting plasma glucose （FPG）, 2-hour postprandial glucose （2hPG）, serum total cholesterol （TC） and triglyceride （TG） were observed before and after treatment for the evaluation of efficacy and safety. Results The total effective rate was 96.67% in the observation group and was 77.50% in the control group, indicating that the observation group had better efficacy on clinical manifestations （P〈0.05）. FPG, 2hPG, TC and TG were improved in both groups after treatment （P〈0.05 or P〈0.01 compared with those before treatment）, and the improvement in the observation group was superior to that in the control group （P〈0.05 or P〈0.01）. The observation group had less side effects during the treatment （P〈0.01）. Conclusion Metformin plus Yangyin Qingre Recipe is effective and safe for the treatment of T2DM patients with yin deficiency and excessive heat syndrome.

关 键 词：2型糖尿病 中西医结合疗法 养阴清热经验方 治疗应用 阴虚热盛证 

分 类 号：R255.4[医药卫生—中医内科学]