含三甲氧苄嗪的细胞外液性停搏液对未成熟兔心肌的作用  

Effect of addition of trimetazidine to two crystalloid cardioplegias on immature myocardium during global ischemia

作　　者：梅运清[1] 龙村[1] 程邦昌[2] 温福兴[1] 张燕婉 史世勇 

机构地区：[1]中国协和医科大学心血管病研究所阜外心血管病医院麻醉体外循环研究室,北京100037 [2]湖北医科大学第一附属医院胸心外科,武汉430060

出　　处：《安徽医科大学学报》2000年第4期260-263,共4页Acta Universitatis Medicinalis Anhui

摘　　要：目的　探讨两种晶体停搏液中 (ModifiedSt .ThomasNo 1 MST、Tyerssolution)加入细胞保护剂三甲氧苄嗪对未成熟心肌的作用。方法　以离体灌注幼兔心为研究对象 ,观察两种晶体停搏液在幼兔心 14℃缺血 2h后血流动力学、冠脉流出液心肌酶和心肌生化的变化。结果　与对照组相比 ,三甲氧苄嗪可明显提高晶体停搏液对离体灌注幼兔心功能的恢复 ,明显减少心肌酶的漏出和氧自由基的生成 (P <0 0 5 ) ,增加高能磷酸盐的储存 (P <0 0 5 )。结论　三甲氧苄嗪可明显提高晶体停搏液对未成熟心肌的保护效果。Objective To investigate the effect of addition of trimetazidine to two cardioplegias (Modified St. Thomas No 1-MST、 Tyers solution, and final concentration of each solution was 10 -6 mol·L -1) on immature myocardium. Methods To observe the change of hemodynamics, myocardial biochemistry of the perfused immature rabbit heart in vitro for two hours of ischemia. Results Compared with the control group, cardioplegias containing trimetazidine could markedly enhance the post-ischemic hemodynamics, tremendously lower the myocardial enzyme leakage and production of oxygen free radical, and improve high-energy phosphates preservation. Conclusion Cytoprotective agent trimetazidine can significantly improve the myocardial protective effect of the two crystalloid cardioplegias on immature heart.

关 键 词：曲美他嗪 药理学 心肌 外液性停搏液 

分 类 号：R972[医药卫生—药品]