鸡新城疫-传染性支气管炎-禽流感(H9亚型)三联灭活疫苗对H9亚型禽流感流行毒株的保护效果  

Protective Efficiency of the Newcastle Disease,Infectious Bronchitis and Avian Influenza(H9 subtype)Triple Inactivated Vaccine Against Epidemic H9 Subtype AIV Strains

作　　者：章振华[1] 李林[1] 沈佳[1] 景小冬[1] 张建伟[1] 郑小兰[1] 史爱华[1] 姜北宇[1] 

机构地区：[1]北京市农林科学院畜牧兽医研究所畜禽疫病防控技术北京市重点实验室,北京100097

出　　处：《动物医学进展》2013年第9期11-14,共4页Progress In Veterinary Medicine

基　　金：北京市科技计划项目(Z111105061211002);北京市优秀人才项目(2010D002020000013)

摘　　要：为了检验鸡新城疫、传染性支气管炎、禽流感(H9亚型)三联灭活疫苗对H9亚型禽流感病毒流行毒株的免疫保护效果,将鸡新城疫、传染性支气管炎、禽流感(H9亚型)三联灭活疫苗免疫接种21日龄SPF鸡,免疫接种后3周采血测定AI(H9)HI抗体,并用2004年—2012年分离的8株H9亚型禽流感病毒对免疫接种鸡进行攻毒试验。结果显示,试验鸡免疫接种三联灭活苗后21d,其H9 HI抗体效价可达11.88log2,可抵抗8个不同H9亚型禽流感流行毒株的攻击,总攻毒保护率达92.50%(37/40)。鸡新城疫-传染性支气管炎-禽流感(H9亚型)三联灭活疫苗中H9亚型禽流感毒株具有良好的免疫原性,能抵抗不同年代不同地区分离的H9亚型禽流感流行毒株的攻击。To monitor the protective efficiency of the newcastle disease,infectious bronchitis and H9 subtype avian influenza triple inactivated vaccine, 21 days SPF chickens were inoculated with the triple vaccine. Three weeks after immunization, the H9 HI antibody titers of the chickens were determined, and the chickens were challenged with eight epidemic strains of H9 subtype avian influenza virus isolated during 2004 2012. The results revealed that the H9 HI antibody titers rises to 11.88 log2 at 21 days after immuni AIV-H9 strains of different years in different regions.

关 键 词：鸡新城疫 传染性支气管炎 H9亚型禽流感 三联灭活苗 流行毒株 免疫效力 

分 类 号：S852.659.5[农业科学—基础兽医学] S852.659.6[农业科学—兽医学]