血液灌流联合血液透析对慢性肾衰竭患者微炎症状态的影响  

The effects of hemoperfusion and hematodialysis on microinflammatory state in chronic renal failure patients

作　　者：杨伟鹏[1] 黄泽伟[1] 许细惠[1] 李长青[1] 

机构地区：[1]广东省潮州市中心医院肾内科,潮州521000

出　　处：《江西医药》2013年第6期489-491,共3页Jiangxi Medical Journal

摘　　要：目的观察血液灌流联合血液透析对慢性肾衰竭患者微炎症状态的影响。方法选择2012年1月至2012年12月在我院治疗的92例慢性肾衰竭尿毒症患者,随机均分成血液灌流联合血液透析治疗组(观察组)或血液透析治疗组(对照组),分别于治疗前、后测患者白细胞介素-1(IL-1)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)及C反应蛋白(CRP)水平。结果两组患者在治疗前IL-1、IL-6、TNF-α和CRP都没有显著性差异(P>0.05),观察组患者在治疗后的IL-1、IL-6、TNF-α和CRP都显著低于对照组患者(P<0.05)。结论慢性肾衰竭患者存在微炎症状态,血液灌流联合血液透析可显著改善患者的慢性炎症状态,值得在临床推广应用。Objective To observation the effects of hemoperfusion and hematodialysis on microinflammatory state in chronic renal failure patients. Methods 92 patients with chronicrenal failure were randomly divided into hemoperfusion and hematodialy- sis （observation group） or the hematodialysis （control group） in our hospital from January 2012 to January 2012. Then test the lev- ds of interleukin-I （IL-I）, interleukin-5 （IL-5）, tumor necrosis factor-a（TNF-a）and C react protein （CRP） before and after treat- ment. Results There were no significant differences in the IL-1, IL-6, TNF-a and CRP between two groups before treatment （P〉 0.05）. However, they in the observation group were significant better than those in the control group after treatment （P〈0.05）. Conclusion There are high levels of microinflammatory factors in CRF patients. The hemoperfusion and hematodialysis are an ef- fective method to remove increased inflammatory factors in chronic renal failure patients. It can be as preferred method to treat hepatolithus.

关 键 词：血液灌流 血液透析 慢性肾衰竭 微炎症状态 

分 类 号：R692.5[医药卫生—泌尿科学]