紫金胶囊对鸭乙型肝炎病毒的作用  

Experimental researches on antiviral activity of Zijin capsules against Duck Hepatitis B Virus

作　　者：陈家春[1] 聂广[1] 蔡大勇[1] 陈鸿珊[2] 李壮[2] 

机构地区：[1]湖北中医学院,湖北武汉430061 [2]中国医学科学院医药生物技术研究所,北京100050

出　　处：《中国医院药学杂志》2000年第10期587-589,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的 :观察紫金胶囊在鸭体内抗鸭乙型肝炎病毒的作用。方法 :采用 1日龄北京雏鸭静脉注射鸭乙型肝炎病毒 ,7d后开始给鸭口服紫金胶囊 ,连续 10d ,分别在给药前、给药后第 5天和第 10天及停药后第 3天取血清 ,检测鸭血清鸭乙型肝炎病毒DNA水平 ,观察药物对鸭血清鸭乙型肝炎病毒DNA的影响。结果 :紫金胶囊 2 0g·kg-1·d-1,在给药第 5天和第 10天能明显抑制鸭血清DHBV DNA水平 (P <0 .0 1) ,10 g·kg-1·d-1也具有一定的抑制作用 (P <0 .0 5 ) ,而且停药后未见血清DHBV DNA水平回升现象。结论 :紫金胶囊在鸭体内对DHBV DNA具有明显的抑制作用。OBJECTIVE:To observe antiviral activity of Zijin capsule against DHBV in the duck body.METHODS:Animal model was made by injecting DHBV into the veins of one day old Beijing duck.In the seventh day after infected by DHBV,Zijin capsule was given by oral in group Ⅰ(5 g·kg -1 ·d -1 ),group Ⅱ (10 g·kg -1 ·d -1 ),group Ⅲ(20 g·kg -1 ·d -1 ),and detected the levels of DHBV in the duck blood sera obtained separately in the day before giving Zijin capsule,the fifth day and tenth day after giving zijin capsule,and the third day after withdrawing Zijin Capsule.RESULTS:The levels of sera DHBV DNA were decreased in the treatment group Ⅲ ( P < 0.01 ),and in the treatment group Ⅱ ( P < 0.05 ). No changes of the levels of sera DHBV DNA were found in the two treatment groups in the third day after withdrawing Zijin capsule.CONCLUSIONS:These results suggested that Zijin capsule markedly inhibited duck hepatitis virus replication. [

关 键 词：紫金胶囊 鸭乙型肝炎病毒 乙型肝炎 

分 类 号：R259.126.2[医药卫生—中西医结合] R286.87[医药卫生—中医内科学]