吸收促进剂对复方替硝唑单向缓释膜中药物渗透性的影响  

Influence of absorption promoter on penetration of compound tinidazol single-way sustaine-release films

作　　者：鄢海燕[1] 邹纯才[1] 张艳秋[1] 

机构地区：[1]佳木斯大学附属口腔医院,黑龙江佳木斯154003

出　　处：《中国医院药学杂志》2000年第10期603-605,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的 :建立复方替硝唑单向缓释膜体外透膜吸收的实验方法。方法 :以恒温双室卡口渗透池为实验装置 ,以羊的肠粘膜为透粘膜屏障 ,采用紫外分光光度法检测替硝唑经粘膜的渗透量及透保护膜层的扩散量。结果 :吸收促进剂能增加替硝唑的透粘膜吸收 ,但各组 (含对照组 )间经配对t检验没有影响。结论 :吸收促进剂在不影响保护膜层的情况下能够提高药膜中替硝唑的单向透粘膜吸收。OBJECTIVE:To establish an in vitro method for penetration test of the film.METHODS:Constant temperature two poor bayonet as experiment unit,intestines mucosa of sheep as protective screen,and UV spectrophotometry for determining the osmosis quantity of tinidazol penetrating mucosa and diffusing quantity of protective films.RESULTS:The absorption promoter can increase the absorption of tinidazol penetrating mucosa,but have no remarkable difference according to t test ( P > 0.05 ).CONCLUSIONS:Absorption promoter can increase the absorption of tinidazol of 3% azone with the film 3% DMSO is the best one. [

关 键 词：替硝唑 单向缓释药膜 吸收促进剂 透粘膜吸收 

分 类 号：R944.9[医药卫生—药剂学] R978.61[医药卫生—药学]