23例肠道病毒71型感染死亡病例临床分析  

Analysis on dinical characteristics of 23 death cases of enterovirus 71 infection

作　　者：李素华[1] 陈均亚[1] 汪洪姣[1] 金江兵 陈益平[1] 

机构地区：[1]浙江省温州市温州医科大学附属育英儿童医院传染科,325027

出　　处：《国际流行病学传染病学杂志》2013年第4期261-263,共3页International Journal of Epidemiology and Infectious Disease

基　　金：温州市科技局科技计划项目（Y20110140）

摘　　要：目的分析浙江省温州地区感染肠道病毒71型（EV71）死亡病例的临床特征。方法回顾性分析温州医学院附属育英儿童医院23例EW1感染死亡病例的临床特点、发病过程及实验室特征。结果23例患儿平均年龄18．6月龄（4月龄～4岁），3周岁以下患儿19例；典型皮疹11例。16例心肺衰竭期死亡患儿入院时小儿危重病例评分（P（船）为（50．6±4．7）分，其中11例于病情加重后24h内死亡，直接死因主要为循环功能衰竭和难治性休克。7例恢复期死亡患儿入院时PCIS为（52．3±6．3）分，除1例机械通气247d死于肺部感染外，其他6例均在进入恢复期后5．5（4～7）d死于脑干脑炎后呼吸中枢抑制。结论死亡患儿病程进展急促，多于急性期死亡。进入恢复期患儿，如存在呼吸机依赖，仍无法存活。Objective To analysis the clinical characteristics of 23 death cases of enterovirus 71 （EVT1） infection in Wenzhon City Zhejiang Province. Methods The clinical characteristics, disease course and laboratory features of 23 death cases of EV71 infection in Yuying Children＇s Hospital Affiliated to Wenzhou Medical University. Results The average age of those children were 18.6 months（4 months- 4 years old）, among them 19 cases were younger than 3 years old, and there were typical rash in 11 cases.Sixteen cases with an average pediatric critical illness score（PCIS） of （50.6±4.7） died in stage of heart and lung exhaustion, including 11 cases who died within 24 hours because of aggravation, the main causes of death were circulation failure and refractory shock. The PCIS score of 7 cases was （ 52.3± 6.3） on admission who died in recovery period, 1 case died of pulmonary infection in the 247th day after mechanical ventilation, the other 6 cases died in the first 5.5 （4-7） days because of respiratory center inhibition after brainstem encephalitis. Conclusion Most of the death cases of EVT1 infection showed rapid process and died in the acute stage. If children in recovery phase relics on breathing machine, they stir cannot survive.

关 键 词：手足121病 肠道病毒71型 死亡 儿童 

分 类 号：R725.1[医药卫生—儿科]