钙调神经磷酸酶对艾滋病患者免疫重建炎症综合征的影响  

Effect of the calcineurin on inmume reconstitution inflammatory syndrome in AIDS

作　　者：陈荷玲[1] 朱彪[1] 

机构地区：[1]杭州310003浙江大学医学院第一附属医院感染科传染病诊治国家重点实验室

出　　处：《国际流行病学传染病学杂志》2013年第4期267-269,共3页International Journal of Epidemiology and Infectious Disease

摘　　要：部分艾滋病患者在使用HAART后的最初几个月发生过度的免疫应答，表现为临床症状的加重，这种现象被称为免疫重建炎症综合征（IRIS）。钙离子作为第二信使普遍存在于真核细胞中，能够引导多种信号通路，其中钙离子／钙调神经磷酸酶-活化T细胞核转录因子（Ca2＋／CN-NTAT）通路对多种细胞的活化、转录和增殖起了重要作用。此文就IRIS的发病机制、钙调神经磷酸酶及Ca2＋／CN-NFAT对IRIS影响情况进行综述。Immune reconstitution inflammatory syndrome （IRIS） is a phenomenon observed in some cases of AIDS patients who have excessive immune response in the first several months after highly active antiretroviral therapy （ HAART）, which manifeets as exaggerated clinical symptoms. Ca2 ＋ can be found in almost all the eukaryocytes as a second messenger and participates in several signal pathways among which Ca2~/CN-NFAT plays an important role in cells activation, transcription and proliferation. The pathogenesis of IRIS, calcineurin and the effect of Ca2＋/CN-NFAT on IRIS are mainly reviewed in this paper.

关 键 词：抗逆转录病毒治疗 高效 免疫重建炎症综合征 钙调神经磷酸酶 

分 类 号：R512.91[医药卫生—内科学]