血液灌流串联高通量血液透析治疗尿毒症继发甲旁亢的观察  

Effects of Combined Therapy with High-flux Hemodialysis and Hemoperfusion in Uremic Patients with Secondary Hyperparathyroidism

作　　者：陈曦[1] 池艳春[1] 郭静[1] 李洪波[1] 

机构地区：[1]哈尔滨医科大学附属第四医院,黑龙江哈尔滨150001

出　　处：《哈尔滨医药》2013年第4期260-261,共2页Harbin Medical Journal

摘　　要：目的观察高通量血液透析(HFHD)联合血液灌流(HP)对尿毒症患者继发甲状旁腺亢进(SHPT)的疗效。方法将40例尿毒症伴SHPT患者随机分为HFHD组和HFHD+HP组,HFHD组行每周1次普通血液透析(HD)加每周2次HF-HD;HFHD+HP组在HFHD组基础上,每2周联合1次HP,治疗12周,比较两组患者治疗前后血钙(Ca),血磷(P)及甲状旁腺激素(iPTH)的情况。结果治疗后,两组患者血磷及iPTH均下降,与治疗前相比有差异(P<0.05),尤以HFHD+HP组明显,治疗后两组结果相比也有显著差异(P<0.05)。血钙均有上升趋势,但无高钙血症出现。结论高通量血液透析对尿毒症继发甲旁亢治疗有效,联合血液灌流后效果更显著。Objective To observe the effects of combined therapy with high -fluxhemodialysis （HFHD） and hemoperfusion（HP） in uremic patients with secondary hyperparathyroidism（SHPT）. Methods Forty patients with secondary hyperparathyroidism caused by uremia were divided randomly into 2 groups ： HFHD group, in which the patients were given HD once a week and HFHD twice a week; HFHD and HP group,in which the patients were given HP once every two weeks,based on the therapy of the HFHD group. We com- pared the concentration of the serum calcium （Ca） ,phosphateand（P） and the intact parathyroid hormone（iPTH） before and after treatment after 12 weeks. Results After the treatment the serum phosphate and iPTH both decreased significantly in the two groups （ P 〈 O. 05 ）, but those changes in the HFHD and HP group were more obvious, the results of the HFHD and HP group were better than the HFHD group （ P 〈 0. 05 ）. The serum calcium concentration were elevated in both group. No hyperealcemia occurred in both group. Conclusion HFHD is effective in the treatment of secondary hyperparathyroidism caused by uremia and the combined therapy with HFHD and HP is a comparatively more effective way.

关 键 词：高通量血液透析 血液灌流 尿毒症 继发性甲状旁腺功能亢进 

分 类 号：R582.1[医药卫生—内分泌]