EphB4-EphrinB2双向信号传导在骨重建中的作用  

Effects of bidirectional EphB4-EphrinB2 signaling on bone remodeling

作　　者：范文斌[1] 赵建宁[1] 包倪荣[1] 

机构地区：[1]南京大学医学院临床学院南京军区南京总医院骨科,江苏南京210002

出　　处：《中国骨伤》2013年第8期705-708,共4页China Journal of Orthopaedics and Traumatology

基　　金：国家自然科学基金青年基金项目(编号:81000814)~~

摘　　要：Eph-Ephrin双向信号传导机制是近年来细胞间的通讯机制的研究热点,在神经系统、血管内皮系统及肿瘤形成和转移方面发挥着重要的作用。研究发现该信号传导系统在骨重建中发挥重要作用。破骨细胞上存在EphrinB2配体,成骨细胞前体上存在EphB4受体,以细胞直接接触的方式,通过胞内酪氨酸激酶信号系统,在成骨细胞和破骨细胞内分别产生正向和反向信号,促进成骨细胞前体分化成熟,同时抑制破骨细胞功能,并促进其凋亡。Bidirectional Eph-Ephrin signaling as a focal point of research in cell-cell communications is critical for gen-eration of nerves and vesssels as well as invation and metastasis of tumor cells. The roles for Ephrin-Eph bidirectional signaling in bone remodeling were important. EphrinB2 is expressed on osteoblasts and EphB4 is expressed on osteoclasts. Forward sig-naling through the EphB4 receptor into mesenchymal precursors promotes osteoblast differentiation ,while reverse signaling through the EphrinB2 ligand into osteoclast suppresses differentiation. Signaling between the ligand EphrinB2 and the recep-tors EphB4 explains bidirectional signaling between osteoblasts and osteoclasts ,bone absorption and remodeling ,which may lay a theoretical foundation for identifying drug targeting and preventing and treating bone loss.

关 键 词：信号传导 骨重建 综述文献 

分 类 号：R392.11[医药卫生—免疫学]