上海市乙肝病毒感染家庭聚集性及感染模式研究  

Study on family clustering of hepatitis B virus infection and family infection mode in Shanghai

作　　者：黎健[1] 刘景一[2] 胡家瑜[1] 李燕婷[1] 

机构地区：[1]上海市疾病预防控制中心急性传染病防治科,上海200336 [2]上海市徐汇区疾病预防控制中心防疫科,上海200237

出　　处：《中华疾病控制杂志》2013年第8期681-683,共3页Chinese Journal of Disease Control & Prevention

基　　金："十二五"国家科技重大专项(2012ZX10002-001);上海市卫生局课题(20114072)

摘　　要：目的了解上海市乙肝病毒感染的家庭聚集性状况及其感染模式,为完善乙肝防治策略提供依据。方法 2010年抽取上海市6个区的乙肝病人337例和乙肝表面抗原阳性者292例,对其全部家庭成员进行调查,并采集静脉血5 ml检测乙肝血清学指标。结果 1 567名调查对象乙肝总感染率为77.28%,629户家庭共有15种乙型肝炎病毒(hepatitis B virus,HBV)感染模式,其中以乙肝表面抗体(hepatitis B surface antibody,anti-HBs)和乙肝核心抗体(hepatitis B core antibody,anti-HBc)二项阳性,乙肝表面抗原(hepatitis B surface antigen,HBsAg)、乙肝e抗体(hepatitis Be antibody,HBeAb)、anti-HBc三项阳性和anti-HBs、HBeAb、anti-HBc三项阳性等模式为主,构成比分别为30.64%、26.67%和10.24%。20岁以下年龄组HBV感染率(27.40%)低于其他年龄组(P<0.001);男性家庭成员HBV感染率(78.51%)稍高于女性(76.12%)(P=0.270)。子女的感染率(44.58%)低于父母的感染率(87.77%),差异有统计学意义(P<0.001);丈夫的感染率(89.50%)与妻子的感染率(86.12%)差异无统计学意义(P=0.170)。结论上海市乙肝病毒感染呈家庭聚集性,应对与乙肝病毒感染者共同生活的家庭成员及时接种乙肝疫苗,并做好日常生活中的预防,以阻断因生活接触导致的乙肝病毒感染。Objective To understand family clustering status of hepatitis B virus （HBV） infection and family in- fection mode in Shanghai. Methods A total of 337 patients with hepatitis B and 292 hepatitis B surface antigen （HBsAg） carriers in six districts of Shanghai were sampled in 2010 and all of their family members were subjected to questionnaires, together with 5 ml of venous blood being collected for detection of HBV serology markers. Results The total HBV infec- tion rate was 77.28% in 1 567 subjects. Fifteen kinds of HBV infection modes were observed in 629 families, in which three modes including hepatitis B surface antibody （anti-HBs） and hepatitis B core antibody （anti-HBc） double positive, HBsAg, hepatitis Be antibody（ HBeAb）, anti-HBc triple positive, and anti-HBs, HBeAb, anti-HBc triple positive were in top three with the proportion of 30. 64% , 26. 67% and 10. 24%, respectively. The HBV infection rate below 20-year-old age group （27.40%） was lower than those of other age groups （P 〈0. 001 ）. The HBV infection rate of male family members （78. 51% ） was slightly higher than that of females （76. 12% ） but without statistical significance （P =0. 270）. The infection rate of children （44. 58% ） was lower than that of parents （87. 77% ） with statistical significance （P 〈0. 001 ）. The difference of HBV infection rate between husbands （89. 50% ） and wives （ 86. 12% ） was not statistically significant （P = 0. 170）. Conclusions The HBV infection in Shanghai showed the obvious family-clustering. In order to block the HBV infection within family by close contact, timely hepatitis B vaccination should be administered to family members who live together with HBV carriers, and the prevention of HBV infection should be strengthened in daily family life.

关 键 词：肝炎病毒 乙型 家庭特征 感染 

分 类 号：R373.21[医药卫生—病原生物学]