非酒精性脂肪性肝病与代谢综合征相关性的研究进展  

Research Progress in Association between Non-alcoholic Fatty Liver Disease and Metabolic Syndrome

作　　者：尹秀梅[1] 缪珩[1] 

机构地区：[1]南京医科大学第二附属医院内分泌科,南京210011

出　　处：《医学综述》2013年第17期3186-3189,共4页Medical Recapitulate

摘　　要：非酒精性脂肪性肝病是一组从简单的肝脂肪变性、脂肪性肝炎、肝纤维化到肝硬化的临床病理综合征。它与肥胖、2型糖尿病、血脂紊乱等代谢综合征(MS)的组分关系密切,而胰岛素抵抗可能是他们共同的病理生理学机制。目前广泛接受的理论是"二次打击"学说。脂肪酸和三酰甘油在肝脏沉积造成"第一次打击","第二次打击"则导致了肝细胞损伤、炎症和纤维化。现对当前关于非酒精性脂肪肝和MS的流行病学、病理生理学、临床诊断以及能强烈支持非酒精性脂肪肝是MS组分的发现等进行综述。Non-alcoholic fatty liver disease（NAFLD） is a clinicopalhological syndrome that ranges from simple steatosis to steatohepatitis, fibrosis or cirrhosis of the liver. It is associated with obesity, type 2 diabetes, and dysiipidemia,which are the main components of metabolic syndrome （MS）, whereas insulin resistance probably is their common pathophysiological mechanism. The most widely accepted theory now is the ＂ two-hit hypothesis＂. The ＂ first hit＂ is the accumulation of the fatty acid and triglyceride in the hepatocytes. The ＂second hit＂ leads to hepatocyte injury, inflammation and fibrosis. Here is to make a review of the current knowledge on the epidemiology, pathophysiology and clinical diagnosis of both NAFLD and MS and the find- ings that strongly support NAFLD is a possible component in the cluster of MS.

关 键 词：非酒精性脂肪性肝病 代谢综合征 胰岛素抵抗 

分 类 号：R589[医药卫生—内分泌] R575.5[医药卫生—内科学]