环孢素治疗口腔扁平苔藓的Meta分析  

Cyclosporine for oral lichen planus:A meta analysis

作　　者：冯锦虹[1] 孙玉亮[1] 赵今[1] 

机构地区：[1]新疆医科大学第一附属医院牙体牙髓科,乌鲁木齐830054

出　　处：《新疆医科大学学报》2013年第9期1310-1314,共5页Journal of Xinjiang Medical University

基　　金：新疆医科大学第一附属医院科研专项基金(2011QN06)

摘　　要：目的评价环孢素治疗口腔扁平苔藓的疗效和安全性。方法计算机检索Cochrane图书馆、MEDLINE、EMbase、CBM、CNKI等数据库,收集所有相关随机对照试验(RCT)和半随机对照试验。由2名评价者独立评价研究质量和提取数据,对同质研究采用RevMan5.2软件进行Meta分析。结果纳入5篇环孢素治疗口腔扁平苔藓的RCT文献,其中4篇为比较环孢素和肾上腺皮质激素,1篇为比较环孢素和口泰。Meta分析显示,环孢素和肾上腺皮质激素临床反应的差异无统计学意义[RR=2.94(0.69,12.48)],2种药物在改善患者疼痛[MD=3.90(-3.71,11.52)]、烧灼感[MD=13.12(-9.29,35.54)]、减少红斑面积[MD=26.62(-4.36,57.60)]、降低不良反应发生率[RR=1.16(0.14,10.01)]方面的差异也无统计学意义。肾上腺皮质激素在减少溃疡[MD=15.76(5.48,26.04)]和网纹面积[MD=41.41(13.62,69.20)]方面优于环孢素。环孢素漱口液减轻病损的效果优于口泰[RR=1.53(1.15,2.02)]。结论环孢素与肾上腺皮质激素比较,在疗效和安全性方面无优势,环孢素的疗效优于口泰。Objectives To assess the effectiveness and safety of cyclosporine to treat Oral lichen planus . Methods The Cochrane Library ,MEDLINE ,EMbase ,CBM ,CNKI ,were searched for randomized con-trolled trials or quasi-randomized controlled trials .Quality assessment and data extraction were performed by two reviewers independently .Meta-analysis were performed for the results of homogeneous studies by RevMan5 .2s oftware .Results 5 RCT were included at last .4 studies were about cyclosporine and glu-cocorticoid ,1 study was about cyclosporine and koutai ,Meta-analysis showed the differences between clini-cal response of cyclosporine and steroid had not statistical significance [RR= 2 .94（0 .69 ,12 .48）] .The differences between two medicine to improve pain [MD= 3 .90（-3 .71 ,11 .52）] and burning sensation [MD=13 .12（-9 .29 ,35 .54）] ,reduced erythema area [MD=26 .62（-4 .36 ,57 .60）] ,side-effect [RR=1 .16 （0 .14 ,10 .01）] had not statistical significance Glucocorticoid reduced ulcer [MD = 15 .76 （5 .48 , 26 .04）] and reticulatin area [MD=41 .41（13 .62 ,69 .20）] prior to cyclosporine ,cyclosporine was effective than koutai [RR=1 .53（1 .15 ,2 .02）] .Conclusion Cyclosporine appears no more effective than glucocorti-coid in the treatment of OLP ,cyclosporine was effective than koutai .Since the sample sizes of the included trials are relatively small ,more well-designed large-scale RCTs are required .

关 键 词：口腔扁平苔藓 环孢素 META分析 

分 类 号：R758.6[医药卫生—皮肤病学与性病学]