盐酸米托蒽醌多囊脂质体的制备工艺优化及性能  

Preparation optimization and characterization of DHAD loaded multivesicular liposomes

作　　者：刘源岗[1,2] 郑琪瑶[1] 王士斌[1,2] 

机构地区：[1]华侨大学化工学院,福建厦门361021 [2]华侨大学制药工程研究所,福建厦门361021

出　　处：《化工进展》2013年第6期1395-1400,共6页Chemical Industry and Engineering Progress

基　　金：国家自然科学基金(31000441;31170939);教育部留学回国人员科研启动基金;福建省自然科学基金(2011J01223);中央高校基本科研业务费(JB-JC1009;JB-SJ1009)项目

摘　　要：采用均匀设计优化并制备了平均粒径为58.75μm的载盐酸米托蒽醌多囊脂质体。该多囊脂质体粒度分布较窄,球形度好。Zeta电位、相变温度及稳定性考察均表明该体系稳定性强,适于药物的释放体系。渗漏率结果表明相对于室温(37℃),冰箱(4℃)更有利于载药多囊脂质体的保存。盐酸米托蒽醌平均包封率为90.13%,考察了胆固醇及三油酸甘油酯用量对多囊脂质体药物释放的影响,药物释放符合《药典》规定,无突释效应,且具有较好的体外缓释性能。DHAD loaded multivesicular liposomes （DHAD-MVLs） with the mean diameter of 58.75 μm were prepared using uniform design. The DHAD-MVLs showed narrow particle size distribution and good sphericity. Zeta potential, DSC and drug stability test all revealed that this system was stable and fit for drug delivery system. Leakage rate results indicated that 4℃ was better for drug-loaded MVLs storage compared to 37℃. The average encapsulation efficiency of DHAD was 90.13%. Finally, the influences of cholesterol and trioleate contents on cumulative release were investigated. All groups were in accord with the China Pharmacopoeia 2010, which meant that there were no burst release and the DHAD-MVLs showed better sustained release in vitro.

关 键 词：盐酸米托蒽醌 多囊脂质体 均匀设计 稳定性 缓释 

分 类 号：R318[医药卫生—生物医学工程]