乙型肝炎患者血清HA与AngⅡ的相关性研究  

Correlation of serum hyaluronidase with Ang Ⅱ in hepatitis B patients

作　　者：袁勇[1] 朱洪[1] 

机构地区：[1]海南医学院附属医院中医科,海口570102

出　　处：《重庆医学》2013年第26期3120-3121,共2页Chongqing medicine

摘　　要：目的乙型肝炎患者肝纤维化与血管紧张素Ⅱ(AngⅡ)的相关性研究。方法采用电化学发光和速率法检测92例急性乙型肝炎患者(急性组)、108例慢性乙型肝炎患者(慢性组)和50例健康人群(对照组)透明质酸酶(HA)和AngⅡ的水平,并对结果进行相关分析。结果与急性组和对照组相比较,慢性组HA和AngⅡ的水平明显升高,差异有统计学意义(P<0.05)。急性组和对照组HA和AngⅡ的水平比较,差异有统计学意义(P<0.05)。进一步分析显示,HA和AngⅡ的水平呈正相关(r=0.629,P<0.05)。结论 HA和AngⅡ的水平关系密切,并且参与了肝纤维化的过程,其水平对乙型肝炎患者肝纤维化的病情评估具有指导意义。Objective To study on the correlation of hepatic fibrosis with angiotensin Ⅱ （Ang Ⅱ ） in the hepatitis B patients. Methods The electrochemical luminescence and the rate method were adopted to detect hyaluronidase （HA） and Ang Ⅱ levels in 92 cases of acute hepatitis B （acute group）, 108 cases of chronic hepatitis B（chronie group） and 50 healthy people（control group）, and the detected results were performed the correlation analysis. Results Compared with the acute group and the control group, the HA and Ang Ⅱ levels in the chronic group were increased significantly（P〈0.05）. The HA and Ang Ⅱ levels had statistical differ- ence between the acute group and the control group（P〈0.05）. Further analysis showed that there was a positive correlation be- tween HA and Ang Ⅱ levels（r=0. 629,P〈0.05）. Conclusion There the HA level is closely related with the Ang Ⅱ level,and both of them participate in the process of liver fibrosis, their levels have the guiding significance in evaluation of severity of liver fi- brosis in the patients with hepatitis B.

关 键 词：乙型肝炎 肝纤维化 透明质酸酶 血管紧张素Ⅱ 

分 类 号：R512.62[医药卫生—内科学]