人用精制Vero细胞狂犬病疫苗的保护性试验  

The protection test of purified vero cell rabies vaccine for human use

作　　者：桑爱军[1] 黄仕和[1] 乐威[1] 卢颖[1] 詹小梅 孙继发 吴杰[1] 朱家鸿[1] 曾繁珍[1] 

机构地区：[1]武汉生物制品研究所,武汉430060

出　　处：《微生物学免疫学进展》2000年第1期10-11,共2页Progress In Microbiology and Immunology

基　　金：湖北省科委"九五"科技攻关项目!(编号 991P1 60 2 )

摘　　要：用CTN 1V株生产的精制Vero细胞狂犬病疫苗腹腔免疫小鼠后 ,再用狂犬病毒街毒株SBD0 7脑内和肌肉攻击 ,结果表明稀释 5倍疫苗的保护率分别为 88 9%和 90 % ,且 5倍稀释疫苗的保护效果与原苗相当 ,此研究证明CTN 1V株能用来作为疫苗的生产毒株。Following administration of purified Vero cell rabies vaccine prepared from CTN 1V strain,mice were challenged with SBD07 rabies virus intramuscularly and intrapenitonealy.The results showed the vaccine induced protective rates of 88.9% and 90% respectively at 1∶5 dilution,which were equivalent to those of undiluted vaccine.This study demonstrates CTN 1V strain of rabies virus can be used as production strain for the vaccine.

关 键 词：VERO细胞 狂犬病疫苗 狂犬病街毒株 保护性试验 

分 类 号：R392-33[医药卫生—免疫学]