含青刺果等舒敏特护霜联合他克莫司序贯治疗激素依赖性皮炎64例临床观察  

The Therapeutic Effect of Tacrolimus Ointment and Intensive Moisturizing Cream Containing Prinsepia Utilis Royle oil Extract in Treating 64 Cases of Corticosteroid-dependent Dermatitis

作　　者：朱紫婷 杨小燕 陆洪光[3] 周蓉颖[4] 路永红[5] 陆前进[6] 蔡良敏[6] 廖智灵[6] 涂颖[1] 李娜[1] 李泽春[3] 汪宇[3] 李利[4] 蒋献[4] 周培媚[5] 黄晶[5] 何黎[1] 

机构地区：[1]昆明医科大学第一附属医院皮肤科云南省皮肤病性病研究所,云南昆明650032 [2]薇诺娜皮肤医疗美容门诊部,云南昆明650000 [3]贵阳医学院附属医院,贵州贵阳550004 [4]四川大学华西医院,四川成都610021 [5]成都市第二人民医院,四川成都610017 [6]中南大学湘雅二院,湖南长沙410008

出　　处：《中国皮肤性病学杂志》2013年第9期961-965,共5页The Chinese Journal of Dermatovenereology

基　　金：云南省省院省校合作基金资助项目(2009AD013)

摘　　要：目的观察含青刺果油、马齿苋提取物舒敏特护霜联合他克莫司序贯治疗激素依赖性皮炎的有效性及安全性。方法采用多中心、随机、开放试验研究方法,选取激素依赖性皮炎患者64例,随机分为试验组和对照组,试验组用含青刺果油、马齿苋提取物舒敏特护霜联合他克莫司乳膏连续治疗受试者28d,然后停用他克莫司乳膏,继续每天外用舒敏特护霜2次,再观察28d。对照组仅外用他克莫司乳膏治疗受试者28d,然后停用他克莫司乳膏,再观察28d皮损变化。分别于7,14,28d对其进行皮损评分,并行无创性皮肤检测,患者自评。结果试验组第7,14,28天皮损评分均低于治疗前,差异有统计学意义(P<0.05),与对照组比较,试验组第28d皮损评分低于对照组,差异有统计学意义(P<0.05)。试验组28d时经表皮失水(TEWL)较治疗前低,14,28d表皮含水量较治疗前高,28d的皮脂含量较治疗前高,差异有统计学意义(P<0.05),与对照组比较,28d时TEWL低于对照组,表皮含水量高于对照组,差异均有统计学意义(P<0.05)。试验组患者较对照组患者自觉皮肤平整性、润泽度、干燥程度、紧绷感、灼热感及瘙痒感改善情况有明显改善。试验组及对照组停药后观察28d,试验组复发率3.7%,对照组复发率27.3%。本试验观察期间均未发生不良反应。结论含青刺果油、马齿苋提取物舒敏特护霜联合他克莫司治疗激素依赖性皮炎疗效优于单用他克莫司治疗,单用舒敏特护霜可预防疾病复发,值得在临床推广。Objective To observe the efficacy and safety of tacrolimus ointment and Intensive Moisturizing Cream containing prinsepia utilis royle oil, purslane extract in treating corticosteroid-dependent dermatitis. Methods A muhicenter, randomized, open study was carried on. 64 patients with corticosteroid-dependent dermatitis were randomly divided into experimental and control group. Patients in experimental group were topically treated with Intensive Moisturizing Cream twice daily and 0.03% tacrolimus ointment once daily for 28 days,followed by Intensive Moisturizing Cream alone twice daily for additional 28 days. Patients in control group were topically treated with O. 03% tacrolimus ointment once daily for 28 days. In addition to patients＇ self assessment of disease severity, the lesion score, TEWL value, stratum corneum water content and stratum corneum sebum content were measured on days 7, 14, and 28. Results Compared to pretreatment, the lesion score in the experimental group decreased on days 7, 14 and 28 （ P 〈 0.05 for all time points）. Compared to control group, the lesion score in the experimental group was significantly lower on day 28 （ P 〈 0.05 ）. In comparison with pretreatment, the TEWL value, sebum content and stratum corneum hydration in experimental group were significantly improved by day 28 after treatment （ P 〈 0.05 ）. Additionally, stratum corneum water content in experimental group increased on 14 days after treatment （ P 〈 0.05 ）. In comparison with controls, after 28 days of treatment TEWL in experimental group was lower （ P 〈 0.05 ）, and stratum comeum water content was higher （P 〈 O. 05 ）. Resuhs of Self-assessment showed that patients in the experimental group felt dramatic improvement in skin smoothness, hydration, dryness, tightness, burning and itching. By 28 days after stopping treatment, the recurrent rates for experimental group and control group were 3.7% and 27.3% respectively in the control group. No adverse effects were observed during the study

关 键 词：特护保湿霜 他克莫司乳膏 激素依赖性皮炎 皮肤屏障 TEWL 

分 类 号：R758.25[医药卫生—皮肤病学与性病学]