整合素调控表皮干细胞增殖分化作用机制的研究进展  

The Progress of the Mechanism of Integrin Regulating Epidermal Stem Cell Proliferation and Differentiation

作　　者：李百川[1] 李红丽[2] 

机构地区：[1]第三军医大学学员旅一队,重庆400038 [2]第三军医大学组织学与胚胎学教研室,重庆400038

出　　处：《中国细胞生物学学报》2013年第9期1392-1396,共5页Chinese Journal of Cell Biology

基　　金：第三军医大学基础部本科生"创新杯"奇思妙想项目(批准号:jc2013020);第三军医大学2013年校级大学生创新创业训练计划项目(批准号:201390035002)资助的课题~~

摘　　要：表皮干细胞在损伤修复中的作用日益得到人们的重视,而它的分裂方式、增殖活性对其完成上皮修复至关重要。现已证实,表皮干细胞的增殖分化受到诸如其表面受体、微环境等多因素的影响。整合素主要分布在表皮干细胞的胞膜上,不仅起黏附作用,同时也介导胞外与胞内的双向信息传递,它对表皮干细胞的增殖、迁移及分化等多方面均有显著的调控作用,且整合素表达异常导致表皮干细胞活性降低、分裂方式改变,与多种疾病的发生密切相关。该文就近年来整合素的表达与分布,其调控表皮干细胞增殖分化的作用机制以及整合素异常与疾病的关系等作一综述。The role of epidermal stem cells in the repair after damage is causing for people＇s concern. The way of split and the proliferative activity of it are essential for the epithelization. It has been confirmed that the proliferation and differentiation of epidermal stem cells are influenced by the factors such as receptors and the microenvironment. Integrins are mainly distributed in the membrane of epidermal stem cells, which play the role on adhesion, mediate two-way information transferred, and regulate proliferation, migration and differentiation of epidermal stem cells. Besides, epidermal stem cells＇ activity lower and the split way change caused by integrin abnormal expression is closely related to a variety of diseases. In this paper, the expression and distribution of integrins, the mechanism of integrins regulating proliferation and differentiation of epidermal stem cells and the relationship of integrins abnormally with disease in recent vears are ~11rnrn^riT^rl

关 键 词：整合素 表皮干细胞 增殖分化 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]