糖皮质激素对早产儿脐血中IGF-1和IGF-2表达的影响  

The effect of glucocorticoid on the expression of IGF-1 and IGF-2 in umbilical cord serum of premature infants

作　　者：曹斐[1] 李婷[2] 段涛[2] 苏秀娟[2] 葛玉纯[2] 王陈晨[2] 

机构地区：[1]同济大学医学院,上海200092 [2]同济大学附属第一妇婴保健院,上海200040

出　　处：《现代妇产科进展》2013年第8期618-621,共4页Progress in Obstetrics and Gynecology

基　　金：国家自然科学基金资助项目(No:81170628);上海市卫生局青年科研资助项目(No:2009Y078)

摘　　要：目的:探讨产前单疗程地塞米松注射对早产儿脐血中胰岛素样生长因子1(IGF-1)和胰岛素样生长因子2(IGF-2)表达的影响。方法:将37周前早产的新生儿分为3组,研究组1为接受地塞米松治疗后1周内分娩的新生儿,共48例;研究组2为接受地塞米松治疗后1周后分娩的新生儿,共26例;对照组为未进行地塞米松治疗分娩的新生儿,共19例。出生后分别留取脐血,ELISA法检测脐血中IGF-1和IFG-2水平。结果:(1)3组早产儿的出生体重无显著差异;(2)研究组1min和5min Apgar评分均高于对照组;(3)IGF-1和IGF-2在研究组1、研究组2以及对照组新生儿中的表达均无显著差异;(4)在3组中的适于胎龄儿中,研究组2和研究组1中IGF-2表达水平均较对照组显著降低(PG1∶G0=0.0423,PG2∶G0=0.0099),IGF-1的表达仍未见显著差异。结论:产前单疗程的地塞米松注射可以改变早产儿脐血中的IGF-2的表达,可能与糖皮质激素导致后代生长潜能变化相关。Objective：To explore the effect of single course of dexamethasone injection on the expression of IGF-1 and IGF-2 in umbilical cord serum of premature infants.Method：To divide the premature infants into three groups：the neonatals who delivered within one week after dexamethasone injection were included in group 1,the neonatals who delivered more than one week after dexamethasone injection were included in group 2,the neonatal who didn’t receive dexamethasone injection before born were as control.Results：（1）There was no statistically different of the birth weights among the three groups.（2）The 1-minute and 5-minute Apgar score in group 1 and 2 were higher than the control.（3）The expression of IGF-1 and IGF-2 was not statistically different among the three groups.（4）The expression of IGF-2 in group 1 and group 2 was statistically lower than control just among appropriate gestational age infants,respectively（PG1∶G0=0.0423,PG2∶G0=0.0099）.There was no statistical difference in IGF-1 expression among three groups.Conclusion：The prenatal single course of dexamethasone injection could alter the expression of IGF-2 in umbilical cord serum of premature infants,which may associated with offspring’s growth potential change caused by glucocorticoid.

关 键 词：糖皮质激素 早产 胰岛素样生长因子1 胰岛素样生长因子2 

分 类 号：R722[医药卫生—儿科]