不同精子参数及来源与ICSI结局的相关性研究  

Comparison of the ICSI outcome with sperm of different quality and sources

作　　者：刘倩[1] 吴莲芝[1] 谢青贞[1] 

机构地区：[1]武汉大学人民医院生殖医学中心,武汉430060

出　　处：《现代妇产科进展》2013年第8期651-653,共3页Progress in Obstetrics and Gynecology

摘　　要：目的:探讨不同精子参数及来源与单精子卵胞浆内注射(ICSI)治疗结局的相关性。方法:回顾分析2010年6月至2011年12月在武汉大学人民医院生殖医学中心行ICSI助孕治疗的413个周期,根据精子质量及来源分为4组,非严重少弱的新鲜射出精子组(A1组,244个周期)、严重少弱的新鲜射出精子组(A2组,61个周期)、睾丸精子组(B组,86个周期)、冻融的射出精子组(C组,22个周期)。比较4组的ICSI治疗结局。结果:4组患者的受精率、正常受精率、卵裂率、优胚率、临床妊娠率、胚胎种植率和早期流产率均无显著差异(P>0.05)。结论:精子的质量及来源不影响ICSI治疗的受精及早期妊娠结局。Objective：To investigate the influence of sperm quality and source on the clinical outcome of intracytoplasmic sperm injection（ICSI）.Method：413 ICSI cycles from June 2010 to Dec.2011 in Reproductive Medicine Centre of Renmin Hospital were evaluated retrospectively.Patients were divided into four groups according to the quality and source of sperm.Group A1 included 244 cycles using fresh ejaculated sperm from normal or unsevere oligoasthenotspermia males,goup A2 included 61 cycles using fresh ejaculated sperm from men with severe oligoasthenotspermia,group B included 86 cycles using testicular sperm,and group C included 22 cycles using frozen-thawed ejaculated sperm.The outcome of fertilization and pregnancy were observed.Results：The Fresh ejaculated semen with different quality,testicular sperm and frozen-thawed ejaculated sperm all had similar ICSI outcome（P＆gt;0.05）.Conclusion：The treatment effect of ICSI is not affected by sperm used of different quality and source.

关 键 词：辅助生殖技术 单精子卵胞浆内注射 男性不育 睾丸精子抽提术 冻融精子 

分 类 号：R715.2[医药卫生—妇产科学]