镉、铅、汞、砷和铬致肾损伤机制的研究进展  

Progress in mechanisms of kidney damage induced by cadmium,lead,mercury,arsenic and chromium

作　　者：申云帅[1] 胡建安[1] 

机构地区：[1]中南大学公共卫生学院劳动卫生与环境卫生学系,湖南长沙410078

出　　处：《中国药理学与毒理学杂志》2013年第4期766-768,共3页Chinese Journal of Pharmacology and Toxicology

基　　金：国家自然科学基金(81072331);教育部中央高校基本科研业务费前沿研究重点项目(721500014)~~

摘　　要：重金属镉、铅、汞、砷和铬是最常见的环境和职业危害因素。不同的重金属对人体损伤的表现不尽相同,但都具有肾损伤特性。多年来,国内外学者对这些重金属的肾损伤机制进行了较多的研究。本文综述了其氧化应激、细胞凋亡、金属硫蛋白、生物膜损伤和细胞内Ca2+平衡失调的几种肾损伤机制。Cadmium,lead,mercury,arsenic and chromium are the most common environmental and occupational hazards.They all cause damage to the kidney,despite the difference in the damage to the human body.Mechanisms of kidney damage by these heavy metals have been studied for many years.This paper summarized mechanisms of kidney damage,including oxidative stress,apoptosis,metallothionein,biofilm injury and inbalance of intracellular Ca2＋.

关 键 词：肾 细胞凋亡 金属硫蛋白 生物膜 

分 类 号：R114[医药卫生—卫生毒理学]